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| http://dx.doi.org/10.1016/j.cortex.2025.05.009 | DOI Listing |
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HLA polymorphisms in South Tunisian systemic sclerosis patients: a case-control study.
Clin Rheumatol
September 2025
Histocompatibility Department, Hedi Chaker UH, University of Sfax, Sfax, Tunisia.
Objective: Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease. Genetic factors may play a pivotal role in determining susceptibility to these disorders. HLA associations with SSc, especially HLA class II, were investigated in different populations but not in Tunisia.
View Article and Find Full Text PDFPosttraumatic Stress Disorder Content on TikTok: Cross-Sectional Analysis of Popular #PTSD Posts.
Online J Public Health Inform
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Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, 1225 Center Drive, Gainesville, FL, 32610, United States, 1 (352) 273-6617.
Background: TikTok became an increasingly popular platform for mental health discussions during a major global stressor (COVID-19 pandemic). On TikTok, content assumed to promote user engagement is delivered in a hyperindividually curated manner through a proprietary algorithm. Mental health providers have raised concerns about TikTok's potential role in promoting inaccurate self-diagnoses, pathologizing normal behaviors, and fostering new-onset symptoms after exposure to illness-related content, such as tic-like movements linked to conversion or factitious disorders.
View Article and Find Full Text PDFPreclinical and first-in-human evidence of 4-hydroxybenzoic acid for mitochondrial COQ2 deficiency.
Brain
September 2025
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain.
Primary coenzyme Q (CoQ) deficiency is a mitochondrial disorder with variable clinical presentation and limited response to standard CoQ10 supplementation. Recent studies suggest that 4-hydroxybenzoic acid (4-HBA), a biosynthetic precursor of CoQ, may serve as a substrate enhancement treatment in cases caused by pathogenic variants in COQ2, a gene encoding a key enzyme in CoQ biosynthesis. However, it remains unclear whether 4-HBA is required throughout life to maintain health, whether it offers advantages over CoQ10 treatment, and whether these findings are translatable to humans.
View Article and Find Full Text PDFVolitional Control of Frequency and Intensity in Speakers With and Without Hyperfunctional Voice Disorders.
J Speech Lang Hear Res
September 2025
Department of Speech, Language, and Hearing Sciences, Boston University, MA.
Purpose: Prior studies of vocal auditory-motor control in people with hyperfunctional voice disorders (HVDs) have found evidence of unusually large responses to auditory feedback perturbations of fundamental frequency (0) and more variable voice onset times in unperturbed speech. However, it is unknown whether people with HVDs perform similarly to people with typical voices when asked to make small changes in vocal parameters in volitional tasks. The purpose of this study was to compare performance on minimal movement tasks for 0 and intensity in people with and without HVDs.
View Article and Find Full Text PDFPersonal pronoun comprehension in addressed and non-addressed situations in autistic and nonautistic preschoolers.
J Cogn Dev
March 2025
Department of Communicative Sciences and Disorders, New York University, 665 Broadway, New York, New York 10012.
This research paper explores the role of speaker, listener and real-time social attention for pronoun comprehension in autistic and nonautistic children in northeast United States. We assessed the pronoun comprehension of 22 autistic children (average age of 62 months, range 46-80 months) and 22 nonautistic children (average age 44 months, range 30-57 months) matched on expressive vocabulary scores. We evaluated first- and second-person possessive pronoun comprehension ("my" and "your") using a game in which two experimenters hid stickers and provided clues to their location by providing a verbal clue (e.
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