98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s10620-025-09153-1 | DOI Listing |
Materials (Basel)
August 2025
Key Laboratory of Materials and Surface Technology, Ministry of Education, School of Materials Science and Engineering, Xihua University, Chengdu 610039, China.
To address incomplete die filling, high cracking tendency, and severe die wear in the conventional forging of AISI-410 martensitic stainless steel U-shaped forgings, an optimized billet volume pre-allocation strategy was proposed. Two improved forging schemes for the U-shaped forgings were designed: the Arc Concave Flattening Scheme (adding arc-shaped concave features to the flattening die for corner volume compensation) and Preformed Volume Allocation Scheme (incorporating a preforming step for strategic volume pre-allocation at ends and corners). Finite Element Analysis employing the Oyane damage model and Archard wear model was employed to simulate and optimize the forging process.
View Article and Find Full Text PDFCancer Cell Int
August 2025
Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China.
Chimeric antigen receptor-modified T cell therapy, originally employed in hematological malignancies treatment, has made significant strides in addressing solid tumors in recent years. Presently, second-generation CAR-T therapy has reached clinical implementation, while fifth-generation CAR-T therapy is in active development. However, initial clinical trials in solid tumors have shown limited success, primarily due to the immunosuppressive microenvironment of the tumor and the scarcity of tumor-specific antigens.
View Article and Find Full Text PDFPlant Physiol
August 2025
Department of Pant Science and Landscape Architecture, University of Maryland, College Park, MD 20742, USA.
Catabolism of the auxin indole-3-acetic acid (IAA) to terminate cellular responses primarily occurs in three steps: (i) conjugation of IAA to Asp/Glu, (ii) oxidation of the indole ring by DIOXYGENASE FOR AUXIN OXIDATION (DAO), and (iii) amidohydrolase cleavage of Asp/Glu. This study examines if IAA oxidation historically associated with membranes is mediated by DAO isoforms and if the oxidized auxin product (oxIAA) retains nominal functionality. We show that Arabidopsis thaliana DAO1 exhibits both soluble and auxin-dependent plasma membrane association, and that oxIAA exhibits weak "anti-auxin" activity.
View Article and Find Full Text PDFDig Dis Sci
September 2025
Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, P.O. Box 208019, New Haven, CT, 06520, USA.
Materials (Basel)
April 2025
Shanxi Key Laboratory of Magnesium Matrix Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
The Mg-8Li-3Al-0.3Si dual-phase alloy (LA83-0.3Si) was subjected to six multi-directional forging (MDF) passes in the present work, then its microstructure, mechanical properties, and work hardening and work softening effects were examined and analyzed.
View Article and Find Full Text PDF