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In this work, the wear behavior of nanoclay-epoxy nanocomposites is studied through Response Surface Methodology (RSM) and Artificial Neural Networks (ANN) as predictive models. This study aims to measure mass loss under wear conditions by studying critical parameters like nanoclay wt%, load, speed, time, and water soaking time. Experimental runs are planned based on the Box-Behnken design of RSM to create a regression model, which is then validated by ANOVA analysis. An ANN model is also trained and tested to improve predictive accuracy, performing better than RSM. The results show that wear resistance is greatly enhanced by increasing nanoclay content, which minimizes material loss. Water absorption adversely affects wear performance, resulting in enhanced mass loss caused by plasticization and swelling. The ANN model is more accurate in prediction than RSM, with minimal variation from experimental data. Scanning Electron Microscopy (SEM) analysis gives insights into wear mechanisms. The research demonstrates the efficiency of combining statistical and machine-learning methods for optimizing wear-resistant polymer nanocomposites.
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http://dx.doi.org/10.1038/s41598-025-05263-y | DOI Listing |
Obes Surg
September 2025
Clinique Mutualiste de Pessac, Pessac, France.
Background: Preoperative treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before bariatric surgery has not been studied. Therefore, we investigated the impact of neoadjuvant treatment with GLP-1 RAs on weight loss and postoperative outcomes in patients who underwent sleeve gastrectomy for severe obesity.
Method: A retrospective single-center study was conducted between January 2022 and December 2023.
Obes Surg
September 2025
E-Da Hospital, Kaohsiung City, Taiwan.
Background: We retrospectively evaluated the efficacy of using additional obesity management medications (OMMs) within the first year after undergoing laparoscopic sleeve gastrectomy (LSG).
Methods: We retrospectively analyzed 246 patients who underwent primary LSG in our institution and were followed up for at least 12 months. We collected body weights preoperatively and at three, six, 12, and 24 months postoperatively, along with body composition and laboratory results preoperatively and at 12 months.
Nature
September 2025
Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Cancer-associated muscle wasting is associated with poor clinical outcomes, but its underlying biology is largely uncharted in humans. Unbiased analysis of the RNAome (coding and non-coding RNAs) with unsupervised clustering using integrative non-negative matrix factorization provides a means of identifying distinct molecular subtypes and was applied here to muscle of patients with colorectal or pancreatic cancer. Rectus abdominis biopsies from 84 patients were profiled using high-throughput next-generation sequencing.
View Article and Find Full Text PDFMol Pharm
September 2025
Department of Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, U.K.
We built a custom device to subject an antibody fragment A33 Fab to controlled stress conditions that combined pH, temperature, agitation, and LED-based light exposure in polypropylene microplates; to simulate the real-world challenges it may encounter during storage and transportation and to evaluate the key degradation routes in Fab formulations. We also explored the addition of Tween 80 as a surfactant and the impact of plate surface siliconisation. Monomer loss and fragmentation was monitored by size-exclusion chromatography, aggregate formation determined by changes in hydrodynamic radius in DLS, and chemical modifications identified through intact mass analysis by LC-MS, and N-terminal sequencing.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Cardiology, JIPMER, Puducherry, India.
A left ventricular sub-mitral thrombus without an aneurysm is a previously unreported rare occurrence. We aim to bring attention to this finding in a case of colorectal adenocarcinoma.An early 60s-year-old female presented with bleeding per rectum, weight loss and fatigue and was found to have colorectal carcinoma with metastasis based on examination, imaging and biopsy findings.
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