Article Synopsis
- Cortical function remains resilient to neuron loss in aging and neurodegeneration, with a focus on the auditory cortex in mice.
- Using two-photon calcium imaging, researchers observed that after targeted removal of sound-responsive neurons, the representational map recovered within days thanks to initially unresponsive neurons gaining sound responsiveness.
- In contrast, removing inhibitory neurons led to longer-lasting disruptions, emphasizing the role of individual neuron plasticity in maintaining stable sensory processing in the neocortex.
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Article Abstract
Cortical function, including sensory processing, is surprisingly resilient to neuron loss during aging and neurodegeneration. In this Article, we used the mouse auditory cortex to investigate how homeostatic mechanisms protect the representational map of sounds after neuron loss. We combined two-photon calcium imaging with targeted microablation of 30-40 sound-responsive neurons in layer 2/3. Microablation led to a temporary disturbance of the representational map, but it recovered in the following days. Recovery was primarily driven by neurons that were initially unresponsive to sounds but gained responsiveness and strengthened the network's correlation structure. By contrast, selective microablation of inhibitory neurons caused prolonged disturbance, characterized by destabilized sound responses. Our results link individual neuron tuning and plasticity to the stability of the population-level representational map, highlighting homeostatic mechanisms that safeguard sensory processing in the neocortex.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229895 | PMC |
| http://dx.doi.org/10.1038/s41593-025-01982-7 | DOI Listing |
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