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Low abstinence self-efficacy, lack of social support, especially from family and friends, low self-esteem, feeling lonely, and lack of self-control have been considered as risk factors for substance use disorders, but the pathways of these risk factors on drug craving have not yet been determined. Therefore, the present study aimed to evaluate the association between abstinence self-efficacy and perceived social support on the one hand to drug craving in patients referred to substance use treatment centers on the other hand, with loneliness, self-control, and self-esteem as mediating variables. The present study is a descriptive-correlational modeling study. The statistical population of this study included all individuals with a history of substance use referring to substance use treatment centers in Mazandaran province. Of these, 249 individuals were selected using a random cluster sampling method. Data were collected using six validated questionnaires including a demographic part, and questions on substance abstinence self-efficacy e, perceived social support, substance craving, self-esteem, self-control, and loneliness. The data were analyzed using structural equation modeling (SEM) with a partial least squares (PLS) approach to evaluate the relationships between variables. Based on the findings of this study, self-efficacy for drug abstinence was significantly and negatively associated with loneliness (p < 0.001), significantly positively associated with self-esteem (p < 0.001), significantly negatively associated with drug craving (p < 0.001), but no significant association was found with self-control (P = 0.377). Loneliness also was significantly positively associated with drug craving (p < 0.001). On the other hand, perceived social perception was significantly positively associated with drug abstinence self-control (p < 0.001), significantly negatively correlated with loneliness (p < 0.05), and significantly positively correlated with self-control (p < 0.001). However, no significant associations were found between perceived social perception on the one hand and self-esteem (P = 0.891) and drug craving (P = 0.144) on the other one. Further, we found that self-control was not significantly associated with substance craving (P = 0.121). Self-esteem was significantly negatively associated with loneliness (p < 0.001). Finally, a significant and direct association was found with substance craving (p < 0.001), but not with self-control (p = 0.458). Our study revealed that abstinence self-efficacy, loneliness, and social perception play a key role in predicting drug craving and self-esteem. As such, interventions to reduce drug craving might focus on increasing abstinence self-efficacy and social support, reducing loneliness, improving self-esteem, and self-control.
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http://dx.doi.org/10.1038/s41598-025-04194-y | DOI Listing |
Alcohol Alcohol
July 2025
Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University School of Public Health, 121 South Main Street, Providence, RI 02912, USA.
Dry January is a temporary alcohol abstinence challenge where participants commit to abstaining from drinking alcohol for one month. It has grown in popularity since its inception >10 years ago. The current scoping review sought to broadly characterize the peer-reviewed literature on Dry January, summarize its main findings, strengths and limitations, and delineate future research directions.
View Article and Find Full Text PDFBMJ Neurol Open
September 2025
Wolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.
Background: Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular (IM) hydroxocobalamin. This service development project evaluated a self-injection programme (SIP) compared with a nurse-led approach, within an established ambulatory care pathway, with the aim of improving treatment adherence and completion.
View Article and Find Full Text PDFFront Psychol
August 2025
Department of Health Psychology and Center for Applied Psychology, Miguel Hernández University, Elche, Spain.
Introduction: The use of alcohol is a prevalent phenomenon among adolescents. Several brief intervention strategies have been developed to prevent the progression of alcohol use to high-risk levels. The consumer profile, including whether they have consumed one or more substances, may be a key variable in analyzing the effectiveness of interventions.
View Article and Find Full Text PDFbioRxiv
July 2025
Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, CA, 93106-9660.
The incubation of craving is a term coined to characterize the behavioral phenomenon wherein cue-elicited craving strengthens over a period of abstinence. Incubated cocaine-craving is mediated, at least in part, by increased glutamate release within the prelimbic cortex (PL). We hypothesized that this glutamate release stimulates NMDA-type glutamate receptors (NMDARs) leading to calcium-dependent activation of CaMKII signaling that drives incubated craving.
View Article and Find Full Text PDFJ Eat Disord
August 2025
Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Osianderstraße 5, 72076, Tübingen, Germany.
Current guidelines recommend psychotherapy as first-line treatment for eating disorders. Many individuals with eating disorders characterized by binge eating episodes benefit from psychotherapy. However, a substantial subgroup does not achieve abstinence from binge eating.
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