Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1161/CIRCULATIONAHA.124.072909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Plot twist: TET2 clones save the brain.
Cell Stem Cell
August 2025
The Jackson Laboratory, Bar Harbor, ME, USA. Electronic address:
While clonal hematopoiesis (CH) is associated with protection from Alzheimer's disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al. discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.
View Article and Find Full Text PDFis the second most frequently mutated gene in clonal hematopoiesis of indeterminate potential (CHIP), driving hematopoietic stem cell clonal expansion and increasing the risk of myeloid malignancies. Affected individuals often develop atherosclerotic cardiovascular disease, exacerbated by hyperinflammatory -mutant macrophages. Here, we show that the XPO1 nuclear export inhibitor eltanexor significantly reduces atherosclerotic plaque formation in a mouse model of -mutant CHIP.
View Article and Find Full Text PDFLandscape and clinicopathologic features of RAS pathway mutations in chronic myelomonocytic leukemia.
Blood Adv
July 2025
Mayo Clinic, Rochester, Minnesota, United States.
RAS pathway mutations (RASMT) induce proliferative features and promote transformation in chronic myelomonocytic leukemia (CMML). However, the unique clonal landscape and hierarchy of distinct RASMT remain unexplored. To characterize the landscape, architecture and implications of unique RASMT in CMML we evaluated a cohort of 814 patients with CMML.
View Article and Find Full Text PDFTET2-mutant myeloid cells mitigate Alzheimer's disease progression via CNS infiltration and enhanced phagocytosis in mice.
Cell Stem Cell
August 2025
Division of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Clonal hematopoiesis (CH) is associated with many age-related diseases, but its interaction with Alzheimer's disease (AD) remains unclear. Here, we show that TET2-mutant CH is associated with a 47% reduced risk of late-onset AD (LOAD) in the UK Biobank, whereas other drivers of CH do not confer protection. In a mouse model of AD, transplantation of Tet2-mutant bone marrow reduced cognitive decline and β-amyloid plaque formation, effects not observed with Dnmt3a-mutant marrow.
View Article and Find Full Text PDFTET2-Mutant Clonal Hematopoiesis Promotes Heart Failure With Preserved Ejection Fraction.
Circulation
June 2025
Division of Hematology/Oncology, Department of Internal Medicine (T.T., Y.J., B.K., P.C., F.K., A.S., N.P., S.S.C.), UT Southwestern Medical Center, Dallas, TX.