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http://dx.doi.org/10.5414/CPP63293 | DOI Listing |
Sleep Adv
July 2025
Waisman Center, University of Wisconsin, Madison, Madison, WI 53705, United States.
This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS), and their associations with Alzheimer's disease (AD) pathology and symptomatology. A total of 93 adults with DS (aged 25-61 years) from the Alzheimer Biomarker Consortium-DS completed cognitive assessments, MRI and positron emission tomography (PET) scans (assessing amyloid-beta [Aβ] and tau), and a one-night home sleep study using the WatchPAT-300 device. Study partners also reported on depressive symptoms and diagnoses.
View Article and Find Full Text PDFbioRxiv
August 2025
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University. 630 West 168 Street, New York, NY 10032, USA.
Genome-wide association studies (GWAS) have enabled clinicians and researchers to identify genetic variants linked to complex traits and diseases(1). However, conducting GWAS remains technically challenging without bioinformatics expertise due to required data preprocessing, software installation, and analysis scripting (2,3). SAGA is a BASH-based, open-source, fully automated pipeline that integrates three widely adopted tools-PLINK(4), GMMAT(5), and SAIGE(6)-for accessible, robust, and reproducible GWAS.
View Article and Find Full Text PDFPLoS Genet
September 2025
Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.
Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer's disease (LOAD) and provides a rationale for identifying genetic factors associated with disease susceptibility. While numerous studies have established substantial genetic contribution for LOAD, the interpretation of heritability estimates remains challenging. These challenges are further complicated by the binary nature of LOAD status, where estimation and interpretation require additional considerations.
View Article and Find Full Text PDFAmyotroph Lateral Scler Frontotemporal Degener
September 2025
Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
The c.166C > T p.(Pro56Ser) or P56S mutation in the gene was initially identified as a cause of motor neuron disease in Brazil in a large extended pedigree comprising >1,500 individuals including more than 200 cases.
View Article and Find Full Text PDFIISE Trans Occup Ergon Hum Factors
September 2025
Department of Industrial Engineering, Clemson University, Clemson, SC, USA.
Occupational ApplicationsThe analysis of communication, attention, and cognitive engagement relative to leadership and non-technical skills (NTS) is important for understanding the team dynamic within clinical settings. We found negative correlations between passive communication (receiving information instead of dictating information) and leadership scores, suggesting that passive leadership traits lead to weaker technical leadership performance. Additionally, continuously sharing goals and providing affirmations to patients had positive relationships with leadership scores.
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