Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Prior work in predominantly European ancestry populations has explained how the risk associated with demographic, lifestyle, and health factors differs with underlying genetic susceptibility to type 2 diabetes (T2D), but less is known about these relationships in Black Americans.
Methods: We used covariate-adjusted logistic regression models of T2D to examine interactions between a published trans-ancestry derived T2D polygenic risk score (PRS) and various demographic, lifestyle, and health-related factors among 28,251 self-identified Black Americans from six cohort studies.
Results: The results are generally consistent with prior work in White populations. The PRS showed a significant interaction with body mass index, with a greater effect on T2D risk in individuals who were leaner (pinteraction = 0.038).
Conclusion: These results contribute to understanding the relationship between genetics and other T2D risk factors in Black Americans who have a high burden of T2D, potentially informing targeted prevention strategies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235720 | PMC |
| http://dx.doi.org/10.1159/000546100 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diversity in Neuroradiology: A Decade-Long Review of Gender, Racial, and Ethnic Representation Among Fellows.
Acad Radiol
September 2025
Corewell Health, Department of Diagnostic Radiology and Molecular Imaging, Oakland University William Beaumont School of Medicine, 3601 W 13 Mile Rd, Royal Oak, MI 48073.
Introduction: Diversity in medical subspecialties is critical for improving patient care and fostering innovation. However, Neuroradiology remains one of the least diverse Radiology subspecialties, with persistent gender and racial disparities among trainees. This study examines gender, racial, and ethnic representation trends among Neuroradiology fellows over the past decade.
View Article and Find Full Text PDFAssessing Malnutrition in Lung Cancer Resection Patients: Modification of Global Leadership Initiative on Malnutrition (GLIM) Criteria for Implementation in Surgical Practice.
Clin Nutr ESPEN
September 2025
Duke University, Department of Surgery, Division of Trauma, Acute, and Critical Care Surgery, Durham, NC, USA. Electronic address:
Background: Up to 70% of lung cancer may be malnourished. This study aims to examine the effects of malnutrition on outcomes in lung cancer patients undergoing resection using modified GLIM criteria.
Methods: The study utilized the mGLIM criteria to identify malnourished patients.
Obesity Among Children and Adolescents in NHANES August 2021-August 2023: An Examination of Race/Hispanic Origin Subgroup Estimates.
Pediatr Obes
October 2025
National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland, USA.
Background: The National Health and Nutrition Examination Survey provides nationally representative data on child obesity using measured height and weight. Due to COVID-19, the NHANES August 2021-August 2023 cycle had design changes and smaller sample sizes for certain race/Hispanic origin groups. The objective is to explore sex and race/Hispanic origin-specific childhood obesity trends.
View Article and Find Full Text PDFThe association of sleep-related issues with chronic pain and high-impact chronic pain incidence in U.S. adults: a 1-year representative cohort study.
J Pain
September 2025
Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
In this longitudinal cohort study, we used nationally representative data from the U.S. National Health Interview Survey (n = 7,826 for chronic pain; n = 9,195 for high-impact chronic pain [HICP]) to examine the association of trouble sleeping and tiredness with 1-year incidence of chronic pain and HICP in U.
View Article and Find Full Text PDFThe perinatal period, which includes pregnancy and postpartum, is associated with body-image disturbance and increased risk of eating disorder (ED) onset or relapse. ED diagnoses that are most common in the perinatal period are also more prevalent among Black individuals compared to other races. However, existing ED screening tools may miss important cultural nuances within the Black population.
View Article and Find Full Text PDF