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A "penile fracture" is a rare urological emergency. According to international literature, a clinical diagnosis is considered sufficient if the patient's history and clinical appearance are characteristic. Imaging modalities such as sonography, cavernosography, and MRI are appropriate diagnostic tools. Sonography is a fast, inexpensive and widely used imaging method; however, MRI offers a higher resolution. The current literature recommends timely surgical treatment.This is a retrospective, single-centre cohort study including all patients who presented at the University Hospital of Lübeck with a suspected penile fracture between 01 January 2018 and 30 September 2024.Sixteen patients were analysed. Eight patients presented on the day the trauma occurred.MRI morphology confirmed a rupture of the corpora cavernosa in 13 of 16 patients. The suspicion was not confirmed in 3 patients. Sonographic and MRI morphological findings correlated in 11 patients, sonography was false negative in 2 patients and false positive in 2 others. In 1 patient, both sonography and MRI yielded inconclusive results.Clinically, a deviation of the penis was seen in about 23% of fractures, 92% showed a haematoma, and about 23% of the patients with a rupture reported that they had heard a "cracking sound".The diagnosis can be established clinically, sonographically, and via MRI. Sonography is suitable for the initial assessment of whether there is an interruption in the continuity of the tuniga albuginea. In the hands of experienced examiners, this may be sufficient to precisely localize the defect. However, in rare cases where sonographic expertise is limited, MRI serves as a more sensitive imaging technique that can rule out differential diagnoses and localize defects.In summary, according to the literature, an MRI is helpful for treatment planning, but not necessary for surgical treatment. With a correlation of sonography and MRI in 69% of the cases we examined, sonography is a sufficient diagnostic tool for determining the indication for surgery. Based on our data, we consider a positive sonography to be sufficient for the initiation of further therapy. However, based on our evaluation, we would recommend MRI in cases of negative ultrasound findings with persistent clinical suspicion.
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http://dx.doi.org/10.1055/a-2606-4501 | DOI Listing |
J Cereb Blood Flow Metab
September 2025
Achucarro Basque Center for Neuroscience, Leioa, Spain.
Adenosine A receptors (AARs) have shown promising therapeutic properties despite their controversial role in modulating stroke outcome. However, the temporal evolution of cerebral AARs density after cerebral ischemia and its subsequent neuroinflammatory response have been scarcely explored. In this study, the expression of AARs after transient middle cerebral artery occlusion (MCAO) was evaluated in rats by positron emission tomography (PET) with [C]SCH442416 and immunohistochemistry (IHC).
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September 2025
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Background: Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath-hold task can be used to elicit this vasoactive response, but data validity hinges on subject compliance. Determining breath-hold compliance often requires external monitoring equipment.
View Article and Find Full Text PDFHum Brain Mapp
September 2025
Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Perinatal stroke is a vascular injury occurring early in life, often resulting in motor deficits (hemiplegic cerebral palsy/HCP). Comorbidities may also include poor neuropsychological outcomes, such as deficits in memory. Previous studies have used resting state functional MRI (fMRI) to demonstrate that functional connectivity (FC) within hippocampal circuits is associated with memory function in typically developing controls (TDC) and in adults after stroke, but this is unexplored in perinatal stroke.
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September 2025
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Background: Tumefactive demyelination (TD) is a rare variant of multiple sclerosis (MS) characterized by tumor-like lesions that often require aggressive management. Genome-wide association studies (GWAS) identified variants associated with MS; similar analyses in TD are lacking.
Objective: A GWAS was performed to identify variants associated with TD.
J Mater Chem B
September 2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China.
Correction for 'Dual drug-loaded metal-phenolic networks for targeted magnetic resonance imaging and synergistic chemo-chemodynamic therapy of breast cancer' by Li Xia , , 2024, , 6480-6491, https://doi.org/10.1039/D4TB00462K.
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