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Nanomedicines are nanoscale, biocompatible materials that offer promising alternatives to conventional treatment options for brain disorders. The recent technological developments in artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), are transforming the nanomedicine field by improving disease diagnosis, biomarker identification, prognostic assessment and disease monitoring, targeted drug delivery, and therapeutic intervention as well as contributing to computational and methodological developments. These advancements can be achieved by analysis of large clinical datasets and facilitating the design and optimization of nanomaterials for testing. Such advancement offers exciting possibilities for the improvement in the management of brain disorders, including brain cancer, Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where early diagnosis, targeted delivery, and effective treatment strategies remain a great challenge. This review article provides an overview of recent advances in AI-based nanomedicine development to accelerate effective and quick diagnosis, biomarker identification, prognosis, drug delivery, methodological advancement and patient-specific therapies for managing brain disorders.
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http://dx.doi.org/10.3389/fmed.2025.1599340 | DOI Listing |
Ann Am Thorac Soc
September 2025
Brigham and Women's Hospital, Division of Sleep and Circadian Disorders, Boston, Massachusetts, United States.
Rationale: There are insufficient data to inform the management of central sleep apnea (CSA) in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Nocturnal oxygen therapy (NOT) has been postulated to benefit CSA patients with HFrEF, but has not been rigorously studied. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.
View Article and Find Full Text PDFNeurology
October 2025
Department of Radiology, Mayo Clinic, Rochester, MN.
Background And Objectives: The relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.
Methods: From the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores and cognitive status) and had quantified serial imaging outcomes (amyloid-PET burden [centiloid] and white matter hyperintensities from MRI [WMH, % of intracranial volume]).
Neurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, UC Davis Medical Center, Sacramento, CA.
Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.
Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.
Clin Nucl Med
September 2025
Department of Nuclear Medicine & PET/CT, Mahajan Imaging & Labs.
SCN2A gene mutations, which affect the function of the voltage-gated sodium channel NaV1.2, are associated with a spectrum of neurological disorders, including epileptic encephalopathies and autism spectrum disorders. Advanced imaging modalities such as magnetic resonance imaging (MRI) and positron emission tomography (PET) have been instrumental in elucidating the neuroanatomic and functional alterations associated with these mutations.
View Article and Find Full Text PDFJ Neurophysiol
September 2025
Department of Radiology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang 110004, China.
Neonatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of developmental disorders and permanent central nervous system damage, with functional recovery closely linked to myelin sheath integrity. This study aimed to analyze the expression of pH and the voltage-gated proton channel (Hv1) in the brains of neonatal pigs with HIE at various time points, alongside changes in myelin-related proteins. MRI was employed to localize the basal ganglia and assess pH changes post-hypoxia-ischemia, while immunofluorescence staining was used to evaluate Hv1, myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and myelin-associated glycoprotein (MAG).
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