Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Breakdown of calcium network is closely associated with cellular aging. Previously, we found that cytosolic calcium (CytoCa) levels were elevated while mitochondrial calcium (MitoCa) levels were decreased and associated with metabolic shift in aged intestinal stem cells (ISCs) of Drosophila. How MitoCa was decoupled from the intracellular calcium network and whether the reduction of MitoCa drives ISC aging, however, remains unresolved. Here, we show that genetically restoring MitoCa can reverse ISC functional decline and promote intestinal homeostasis by activating autophagy in aged flies. Further studies indicate that MitoCa and Mitochondria-ER contacts (MERCs) form a positive feedback loop via IP3R to regulate autophagy independent of AMPK. Breakdown of this loop is responsible for MitoCa reduction and ISC dysfunction in aged flies. Our results identify a regulatory module for autophagy initiation involving calcium crosstalk between the ER and mitochondria, providing a strategy to treat aging and age-related diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116733 | PMC |
| http://dx.doi.org/10.1038/s41467-025-60196-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bidirectional Hypoxic Extracellular Vesicle Signaling Between Müller Glia and Retinal Pigment Epithelium Regulates Retinal Metabolism and Barrier Function.
Biology (Basel)
August 2025
Department of Oral Biology, The Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.
The retina is highly sensitive to oxygen and blood supply, and hypoxia plays a key role in retinal diseases such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Müller glial cells, which are essential for retinal homeostasis, respond to injury and hypoxia with reactive gliosis, characterized by the upregulation of the glial fibrillary acidic protein (GFAP) and vimentin, cellular hypertrophy, and extracellular matrix changes, which can impair retinal function and repair. The retinal pigment epithelium (RPE) supports photoreceptors, forms part of the blood-retinal barrier, and protects against oxidative stress; its dysfunction contributes to retinal degenerative diseases such as AMD, retinitis pigmentosa (RP), and Stargardt disease (SD).
View Article and Find Full Text PDFPiezo1 in heart failure: A new perspective from cytomechanical sensing to diverse cellular pathways.
Mol Biol Rep
September 2025
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, 301600, Tianjin, China.
Piezo1, a mechanosensitive cation channel characterized by its distinctive transmembrane trimeric structure, plays a pivotal role in mediating cellular responses to mechanical stimuli. It facilitates calcium influx, and recent studies highlight its involvement in heart failure (HF) pathophysiology, where its dysregulation significantly contributes to disease progression. Specifically, Piezo1 upregulation impacts diverse cellular processes across cardiovascular cell types, including cardiomyocytes, fibroblasts, endothelial cells (ECs), and vascular smooth muscle cells (VSMCs).
View Article and Find Full Text PDFProtein networks: integrating pathways for plant heat stress adaptation.
Funct Integr Genomics
September 2025
Department of Chemistry, College of Science, Northern Border university, Arar, Saudi Arabia.
Plants' immobility renders them highly vulnerable to heat stress, which disrupts water relations, photosynthesis, respiration, and cellular homeostasis, ultimately reducing growth and yield. To survive, plants deploy a multifaceted heat stress response (HSR) that integrates calcium signaling, molecular chaperones, antioxidant enzymes, and phytohormonal networks. This review synthesizes recent advances in understanding the molecular crosstalk between phytohormones and protein synthesis during plant heat stress responses, with a particular focus on two key HSR modules: protein synthesis pathways, especially heat shock proteins (HSPs), and phytohormone signaling networks involving abscisic acid, cytokinins, ethylene, salicylic acid, and jasmonic acid.
View Article and Find Full Text PDFRestoring the enteric neuroimmune crosstalk via hollow mesoporous polydopamine nanoparticles in inflammatory bowel disease treatment.
J Control Release
August 2025
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China. Electronic address:
The enteric neuro-immune crosstalk is considered crucial for maintaining intestinal mucosal immune homeostasis, offering a promising way to achieve clinical cure of inflammatory bowel disease (IBD). However, neuron loss, disruption of the enteric nervous system, and impaired acetylcholine (ACh) biosynthesis in the intestine are prevalent in IBD patients, which severely disrupts enteric neuroimmune function. Exploring effective treatments for the disease has become the research hotspot and the goal of current IBD research.
View Article and Find Full Text PDFSelf-measured home orthostatic hypo- and hypertension - prevalence and associations with atherosclerosis and arterial stiffness.
Am J Hypertens
August 2025
Department of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linkoping University, Norrköping, Sweden.
Background: Orthostatic blood pressure (BP) dysregulation measured in-office predicts cardiovascular risk. However, the prevalence of self-measured home orthostatic hypo- and hypertension, and their association with markers of atherosclerosis have not yet been described in a large sample of the general population.
Methods: We performed cross-sectional analyses of home orthostatic BP reactions and pulse wave velocity (PWV), coronary artery calcium score (CACS), and carotid plaques in 4556 Swedish CArdioPulmonary bioImage Study (SCAPIS) participants who had performed home BP measurements and two home standing BP measurements Omron M10-IT device).