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A novel assessment approach for multi-dimensional microplastic particles (Multi-MPs), grounded in the objective weighting method, is applied to the soil and groundwater alongside the middle and lower reaches of the Yellow River. The results showed that MPs concentration ranged from 426 to 3011 n∙kg in soil layer (0-15 cm). Dominant soil MPs exhibited sizes ranging from 25 to 150 μm (61.4 % - 88.3 %), with fibrous (51.3 % - 71.1 %), and transparent (26.2 % - 60.4 %) constituents, respectively. The polymer types mainly included polyethylene (PE), polypropylene (PP), and polyethylene terephthalate (PET). The abundance of MPs in groundwater ranged from 2.28 to 20.5 n∙L. The main characteristics of MPs in groundwater were sizes of 25-150 μm (90.2 % - 97.1 %), with fibrous (17.7 % - 74.0 %), and transparent (26.1 % - 60.3 %) constituents, and PE/PP/PET polymer composition. Land-use type was the main factor determining the distribution of MPs in soil, and the community composition of MPs in soil and groundwater varied accordingly. The Multi-MP risk assessment index revealed that soil risks were predominantly ranked at Class Ⅲ (medium), while 23.1 % of groundwater samples reached Class Ⅳ (high-risk). These findings highlight the critical need to prioritize groundwater microplastic pollution in environmental management. This study aims to develop a holistic approach incorporating multidimensional indicators to enhance the risk assessment framework for MPs. Future studies should focus on long-term ecological impacts of MPs and the development of standardized protocols for multi-dimensional risk assessment to guide targeted mitigation strategies.
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http://dx.doi.org/10.1016/j.jhazmat.2025.138698 | DOI Listing |
J Clin Invest
September 2025
The University of Texas at Austin, Austin, United States of America.
Background: Following SARS-CoV-2 infection, ~10-35% of COVID-19 patients experience long COVID (LC), in which debilitating symptoms persist for at least three months. Elucidating biologic underpinnings of LC could identify therapeutic opportunities.
Methods: We utilized machine learning methods on biologic analytes provided over 12-months after hospital discharge from >500 COVID-19 patients in the IMPACC cohort to identify a multi-omics "recovery factor", trained on patient-reported physical function survey scores.
Curr Atheroscler Rep
September 2025
Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, 521 19th Street South-GSB 444, Birmingham, AL, 35233, USA.
Purpose Of Review: This review examines cardiovascular disease (CVD) risk prediction models relevant to older adults, a rapidly expanding population with elevated CVD risk. It discusses model characteristics, performance metrics, and clinical implications.
Recent Findings: Some models have been developed specifically for older adults, while several others consider a broader age range, including some older individuals.
Eur Arch Paediatr Dent
September 2025
Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, Brazil.
Purpose: This systematic review provides a critical evaluation, synthesis of the existing literature on isotretinoin's effects on craniomaxillofacial bone.
Methods: Following the PRISMA guidelines and registered in PROSPERO, the review was conducted in August 2024 across various databases. Eligible in vivo studies were analysed for their assessment of isotretinoin's effects on craniomaxillofacial bone.
Dermatol Ther (Heidelb)
September 2025
Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138, Bologna, Bologna, Italy.
Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) have gained prominence for their efficacy in treating type 2 diabetes and obesity. Recent evidence suggests that their pleiotropic effects-beyond glycemic control and weight loss-include anti-inflammatory, immunomodulatory, and antioxidative effects, which may beneficially support various dermatologic conditions such as psoriasis, hidradenitis suppurativa, acanthosis nigricans, and Hailey-Hailey disease. However, GLP-1 RAs are also associated with emerging cutaneous adverse drug reactions, including bullous, exanthematous and vasculitic manifestations, and other rare side effects.
View Article and Find Full Text PDFBiol Trace Elem Res
September 2025
Laboratório de Testes Farmacológicos E Toxicológicos - LEFT, Universidade Federal Do Rio Grande, Instituto de Ciências Biológicas, Av. Itália Km 8 Bairro Carreiros, CEP 96203-900, Rio Grande, Rio Grande Do Sul, Brasil.
This study aimed to evaluate fluoride concentrations in a variety of commonly consumed teas and Herbal infusions in Brazil and assess potential Health risks associated with their ingestion. A total of 21 samples were analyzed, including 12 loose-leaf and 9 commercially bagged products. Fluoride quantification was performed using a validated spectrophotometric method, and a deterministic and probabilistic human Health risk assessment was conducted.
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