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Introduction: Previous studies have shown that, during the coronavirus disease 2019 (COVID-19) pandemic, nurses were being reassigned to non-COVID-19 wards, opting to take leave, or resigning because of concerns of infecting their families. Even so, many nurses decided to continue working. However, a literature review revealed a lack of research clarifying how nurses coped with their anxiety and came to the decision to work in a COVID-19 intensive care unit.
Objective: To determine the process by which nurses living with their families decided to work in an intensive care unit during the COVID-19 pandemic and the factors that influenced their decision.
Methods: Fifteen registered nurses who lived with their families and decided to work in a COVID-19 intensive care unit during the pandemic were recruited for an individual, semi-structured interview. Charmaz's constructivist grounded theory was used to analyze the transcripts.
Results: Four core categories were identified. When the nurses perceived their facility would accept a patient with COVID-19, they: (1) assessed the risk of infection to their family, (2) weighed their anxiety against their sense of mission, (3) reduced the risk of infection, and (4) discussed the decision with their family members.
Conclusion: The decision involved fear of infecting families, trust in the hospital, and sense of mission. Hospitals' consideration of the situation was important in motivating employees and reducing anxiety. There was a gender bias in this study. The large number of male participants resulted from the characteristics of the participating COVID-19 intensive care units, reflecting gender roles in Japan, where men often work and women are responsible for housework and childcare. Facilities and managers should foster a workplace culture that values employees, even in ordinary times. Our findings may help healthcare organizations support nurses in an emerging infectious disease pandemic and ensure nurses are available in healthcare systems with limited resources.
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http://dx.doi.org/10.1177/23779608251345709 | DOI Listing |
JCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Kidney360
September 2025
Department of Pediatrics, Division of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, United States.
Background: Dialysis in neonates with ESKD is often associated with multiple comorbidities and the need for more intensified dialysis regimens. With recent advances in prenatal interventions and infant specific KRT, survival of neonates with ESKD has improved over the last decade. Little is known however about the impact on the health care system of improved survival in this population.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute and Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
MS4A4A belongs to the MS4A tetraspan protein superfamily and is selectively expressed by the monocyte-macrophage lineage. In this study, we aimed to evaluate the role of MS4A4A+ macrophages in rheumatoid arthritis (RA) pathogenesis and response to treatment. RNA sequencing and immunohistochemistry of synovial samples from either early treatment-naïve or active chronic RA patients showed that MS4A4A expression positively correlated with synovial inflammation.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Importance: Exposure to inflammation from chorioamnionitis places the fetus at higher risk of premature birth and may increase the risk of neurodevelopmental impairments, though the evidence for the latter is mixed.
Objective: To evaluate whether moderate to severe histologic chorioamnionitis (HCA) is directly associated with adverse motor performance, independent of the indirect mediating effects of premature birth.
Design, Setting, And Participants: This prospective, population-based cohort study recruited participants between September 16, 2016, and November 19, 2019, from referral and nonreferral neonatal intensive care units of 5 southwestern Ohio hospitals.
Patient
September 2025
PPD Evidera Patient-Centered Research, Thermo Fisher Scientific, Waltham, MA, USA.
Background: Migraine care is often suboptimal owing to undertreatment, variation in clinical outcomes and administration methods among existing treatments, and between- and within-individual heterogeneity in the clinical course of migraine. In response to these challenges, preference studies have been increasingly conducted to inform treatment decision-making and development. However, gaps remain in understanding how treatment preferences have been assessed across different migraine studies.
View Article and Find Full Text PDF