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Introduction: There is limited data regarding the prevalence and predictors of diabetes distress in Indians with type 2 diabetes (T2D). The study aimed to determine the occurrence and predictors of diabetes distress in adult persons with T2D.
Methods: In a cross-sectional study, persons with T2D on pharmacotherapy for at least 1 year were evaluated. They were administered three questionnaires namely- Diabetes Distress Scale-17, Patient Health Questionnaire-9, and Morisky Medication Adherence Scale-8. Clinically meaningful data regarding diabetes complications, anthropometry, and biochemical parameters were recorded.
Results: Two hundred persons completed the study (mean age 57 ± 9.89 years, 59% males). Overall 140 (70%) of the patients had diabetes distress (mean DDS score ≥2). Clinically significant diabetes distress (CSDD) that requires a physician's attention (mean DDS score ≥3) was seen in 75 (37.50%) of the study participants. The mean HbA1c was significantly higher in participants with CSDD (10.24 ± 2.01 vs. 7.85 ± 1.14; = <0.001). Both microvascular [retinopathy (28% vs. 5.60%; ≤ 0.001), neuropathy (28% vs. 0%; ≤ 0.001), nephropathy (32% vs. 6.40%; ≤ 0.001)] and macrovascular (CAD 24% vs. 4.80%; ≤ 0.001) and (CVA 6.67% vs. 1.60%; = 0.059) complications were significantly correlated with CSDD. Medication adherence was significantly lower in patients with CSDD (p=<0.001). An increased number of insulin injections increased BMI and HbA1c, and the presence of nephropathy were independent predictors of CSDD.
Conclusion: Diabetes distress is a common co-morbid condition in persons with T2D. CSDD had a significant correlation with poor glycaemic control, higher BMI, presence of nephropathy, and higher number of insulin injections.
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http://dx.doi.org/10.4103/ijem.ijem_170_24 | DOI Listing |
BJGP Open
September 2025
Health Psychology and Behavioural Medicine, Lee Kong Chian School of Medicine, Nanyang Technological University, Nanyang, Singapore.
Background: Diabetic foot ulcers (DFUs) significantly impair health-related quality of life (HRQoL). While clinical predictors are well established, the contribution of psychological factors, particularly in primary care, remains underexplored.
Aim: To examine the sociodemographic, clinical, and psychological determinants of HRQoL in individuals with DFUs to inform development of psychologically informed interventions.
Acute kidney injury is one of the most severe complications of severe malaria, with an overall incidence reaching 60% and a mortality rate of up to 45%. We conducted this study to determine the prevalence of acute kidney injury in malaria, acute kidney injury, associated factors and the impact of acute kidney injury on vital prognosis. This was a multicenter, retrospective, descriptive, and analytical study over a 5-year period from January 1, 2019 to December 31, 2023, in the nephrology and infectious diseases departments and intensive care units of Dakar hospitals.
View Article and Find Full Text PDFNurs Sci Q
October 2025
Associate Professor Emerita, University of Arizona, Tucson, AZ, USA.
Emerging adults with type 1 diabetes (T1D) are vulnerable to diabetes distress, decreased diabetes self-care, and decreased well-being due to simultaneously managing complex self-care demands and meeting developmental goals. Self-transcendence is an inherent human process that helps to mitigate vulnerability and promote a sense of well-being. The purpose of this qualitative descriptive study was to describe the perspectives and behaviors of emerging adults with T1D that reflected self-transcendence and how this process facilitated their diabetes self-care.
View Article and Find Full Text PDFFront Immunol
September 2025
Immunocore Ltd., Abingdon, United Kingdom.
Background: The programmed cell death protein 1 (PDCD1 or PD-1) is a key regulatory immune checkpoint and a major target for therapeutic intervention. In oncology, antibodies blocking the PD-1 pathway are used to activate immune cells to promote anti tumour immunity while in immune-mediated inflammatory diseases, PD-1 agonist molecules have the potential to achieve immune suppression. NK cells are a specialised population of innate lymphocytes able to recognize a large range of distressed cells including damaged tissues in autoimmune and inflammatory conditions.
View Article and Find Full Text PDFJ Pediatr Clin Pract
September 2025
Epidemiology Division, Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Objective: To determine the degree of diabetes-specific distress in children with type 1 diabetes mellitus (T1DM) and its association with demographic characteristics, family and educational situation indicators, glycemic control, complications, and disease duration.
Study Design: A cross-sectional study (Jan-Mar 2025) in Argentina and Chile included 143 T1DM patients (8-17 years, ≥1-year duration). Diabetes distress was measured using the Problem Areas in Diabetes (PAID) questionnaire (0-80; high distress ≥40).