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Background: In 2024, WHO included effective refractive error coverage (eREC) into the results framework of the 14th General Programme of Work, which sets a road map for global health and guides WHO's work between 2025 and 2028. eREC is a measure of both the availability and quality of refractive correction in a population. This study aimed to model global and regional estimates of eREC as of 2023 and evaluate progress towards the WHO global target of a 40 percentage-point absolute increase in eREC by 2030.
Methods: For this systematic review and meta-analysis, the Vision Loss Expert Group analysed data from 237 population-based eye surveys conducted in 76 countries since 2000, comprising 815 273 participants, to calculate eREC (met need / met need + undermet need + unmet need]) and the relative quality gap between eREC and REC ([REC - eREC] / REC × 100, where REC = [met + undermet need] / [met need + undermet need + unmet need]). An expert elicitation process was used to choose covariates for a Bayesian logistic regression model used to estimate eREC by country-age-sex grouping among adults aged 50 years and older. Country-age-sex group estimates were aggregated to provide estimates according to Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) super-regions.
Findings: Global eREC was estimated to be 65·8% (95% uncertainty interval [UI] 64·7-66·8) in 2023, 6 percentage points higher than in 2010 (eREC 59·8% [59·4-60·2]). There were marked differences in eREC between GBD super-regions in 2023, ranging from 84·0% (95% UI 83·0-85·0) in high-income countries to 28·3% (26·4-30·4) in sub-Saharan Africa. In all super-regions, eREC was lower in females than males, and decreased with increasing age among adults aged ≥50 years. Since 2000, the relative increase in eREC was 60·2% in sub-Saharan Africa, 45·7% in North Africa and the Middle East, 41·5% in southeast Asia, east Asia and Oceania, 40·3% in south Asia, 16·2% in Latin America and the Caribbean, 8·3% in central Europe, eastern Europe and central Asia, and 6·8% in the high-income super-region. The relative quality gap ranged from 2·9% to 78·3% across studies, with larger gaps characteristically in regions of lower eREC. Globally, the percentage of those with a refractive need that was undermet reduced between 2000 and 2023, from 10·0% (95% UI 9·5-10·5) to 5·3% (5·1-5·5).
Interpretation: The current trajectory of improvement in eREC and the relative quality gap are insufficient to meet the 2030 target. Global efforts to equitably increase spectacle coverage, such as the WHO SPECS 2030 initiative, and to address equity failings associated with geography, age, and sex, are crucial to accelerating progress towards the 2030 targets. No region is close to achieving universal coverage.
Funding: WHO, Sightsavers, The Fred Hollows Foundation, Fondation Thea, University of Heidelberg, German Federal Ministry for Education and Research.
Translations: For the French, Chinese and Spanish translations of the abstract see Supplementary Materials section.
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http://dx.doi.org/10.1016/S2214-109X(25)00194-9 | DOI Listing |
Br J Ophthalmol
September 2025
Lions Aravind Institute of Community Ophthalmology, Aravind Eye Care System, Madurai, India
Background: The Vision Centre (VC) model evolved to meet primary eye care needs in rural and underprivileged communities, overcoming workforce and resource challenges. Despite over two decades of operation, its impact is not well-documented. We evaluated its effectiveness by comparing prevalence of visual impairment (VI), eyecare utilisation and service coverage among residents within and beyond a 5 km radius of VCs in Theni district, India.
View Article and Find Full Text PDFBr J Nutr
August 2025
Nuh Naci Yazgan University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Kayseri, Turkey.
The study aimed to translate the Eating-Related Eco-Concern (EREC) questionnaire into Turkish, adapt it cross-culturally, and evaluate its psychometric properties. EREC is a ten-item scale measuring how adults consider ecological impact in food choices due to climate change concerns. The study was conducted in Mersin between November 2023 and February 2024 with 442 adults (18-65 years) through face-to-face interviews.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
Department of Chemistry & Chemical Biology, Indian Institute of Technology (ISM) Dhanbad, Dhanbad-826004, India.
Macrolide esterases, which are preponderant drug-inactivating enzymes present inside drug-resistant bacteria, pose a significant threat to the realm of macrolide antibiotics. They dissect the antibiotic's macrolactone ring structure by hydrolyzing the ester moiety, consequently diminishing the antimicrobial efficacy in treating bacterial infections. Motivated by the recently resolved crystallographic structure of an important member of the macrolide esterase - 'Erythromycin Esterase C (EreC)' - we have delved into the catalytic itineraries of the erythromycin hydrolysis utilizing QM/MM methods.
View Article and Find Full Text PDFSurg Endosc
September 2025
Division of Thoracic and Esophageal Surgery, Department of Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
Background: Increasingly, endoscopic techniques such as Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection provide less invasive treatment for early-stage esophageal cancer. However, factors that affect survival after endoscopic resection of esophageal cancer (EREC) are poorly defined. This study aims to build a risk model for patients undergoing EREC, identifying the impact of pathologic risk factors on survival.
View Article and Find Full Text PDFOrphanet J Rare Dis
July 2025
Inserm U1132 Bioscar, Université Paris Cité, Centre Viggo Petersen Hôpital Lariboisière, APHP.Nord, 75010, Paris, France.
Background: Melorheostosis is a rare skeletal and connective tissue disorder with the estimated prevalence of 1/1,100,000. Low prevalence of rare diseases (RDs) can lead to suboptimal knowledge and expertise among clinicians.
Methods: The European Registries for Rare Endocrine and Bone Conditions (EuRREB) facilitates collection of a set of Core Data Elements and a specific dataset within the 'condition specific module' of the Core Registry platform.