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http://dx.doi.org/10.1016/j.bja.2025.04.030 | DOI Listing |
J Palliat Med
September 2025
Skaggs School of Pharmacy & Pharmaceutical Sciences, UC San Diego Health Sciences, San Diego, California, USA.
Artificial intelligence (AI), particularly large language models (LLMs), offers the potential to augment clinical decision-making, including in palliative care pharmacy, where personalized treatment and assessments are important. Despite the growing interest in AI, its role in clinical reasoning within specialized fields such as palliative care remains uncertain. This study examines the performance of four commercial-grade LLMs on a Script Concordance Test (SCT) designed for pharmacy students in a pain and palliative care elective, comparing AI outputs with human learners' performance at baseline.
View Article and Find Full Text PDFJ Laparoendosc Adv Surg Tech A
September 2025
Department of Anesthesiology, Shandong Provincial Third Hospital, Shandong University, Jinan, China.
This study aimed to identify the biomarkers that was associated with the postoperative incisional pain in patients with acute cholecystitis undergoing laparoscopic cholecystectomy surgery (ACC-LC). Sixty ACC-LC patients were enrolled and divided into mild pain (MP) and moderate-to-severe pain (MSP) groups based on their visual analog scale (VAS) scores 24 hours postoperatively. RNA sequencing was used to screen the potential pain associated markers, and ELISA were used to analyze the expression of one identified marker, CXCR5 in peripheral blood mononuclear cells (PBMCs).
View Article and Find Full Text PDFAnesthesiology
September 2025
Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Background: Cardiovascular complications are the leading cause of mortality following liver transplantation (LT) in patients with acute-on-chronic liver failure (ACLF). However, the extent of cardiac impairment in these patients remains unclear. Current risk models, including the CLIF-C-organ failure (CLIF-C-OF), NACSELD-ACLF, and the novel Sundaram ACLF-LT-mortality (SALT-M) scores primarily focus on blood pressure and the use of cardiovascular drugs, without directly assessing biomarkers of cardiac injury.
View Article and Find Full Text PDFArch Gynecol Obstet
September 2025
Faculty of Medicine, University of Lille, 59000, Lille, France.
Purpose: Endometriosis is a chronic, hormone-dependent disease affecting up to 10% of women of reproductive age, often associated with chronic pelvic pain (CPP). Neuropathic pain has been increasingly recognized as a significant component in a subset of patients with CPP related to endometriosis. The study objective was to assess the prevalence of neuropathic-like pain in women with deep endometriosis (DE) and CPP, and to analyze its influence on pain perception and quality of life.
View Article and Find Full Text PDFAmyotroph Lateral Scler Frontotemporal Degener
September 2025
Department of Physiotherapy and Laboratory for Technological Innovation in Health, Federal University of Rio Grande do Norte, Natal, Brazil.
Fatigue remains a poorly understood symptom in individuals with ALS, and little is known about its associtation with other symptoms, including functional impairment, cognition, and pain. To identify the levels of fatigue, pain, ALSFRS-R, and cognition of a Brazilian group of individuals with ALS, in order to verify possible influences between these symptoms and fatigue. This is a cross-sectional study conducted with individuals with ALS who were recruited intentionally, using a non-probabilistic sampling method.
View Article and Find Full Text PDF