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Background: Borderline Personality Disorder (BPD) significantly impacts individuals, causing substantial distress and impairing social, occupational, and other critical areas of functioning. Current tools to assess functioning in BPD are limited and often lack validation in BPD-specific populations. Furthermore, available instruments focus primarily on global functioning rather than specific areas such as cognitive functioning or interpersonal relationships. This study aims to validate the Functioning Assessment Short Test (FAST) in adolescents and young adults with BPD in a Spanish population.
Methods: An observational study was conducted with 216 BPD patients and 107 healthy controls (HC) matched by age and sex. Participants were assessed using the FAST, and additional clinical measures were applied. Internal consistency, inter-rater reliability, exploratory and confirmatory factor analysis, discriminant validity through ROC analysis, and logistic regression were performed to evaluate the psychometric properties of the FAST. Additionally, sensitivity to change was assessed to determine the FAST's responsiveness to clinical improvements.
Results: The FAST demonstrated high internal consistency (Cronbach's alpha = 0.869) and a six-factor structure. Inter-rater reliability analysis indicated excellent agreement (ICC=0.997, 95 % CI=0.991-0.999). The tool showed high discriminant capacity between BPD patients and HC (AUC=0.947), with a cutoff score of >11 achieving 88 % sensitivity and 90.7 % specificity. Sensitivity to change analyses in a subgroup of 35 BPD patients revealed significant effect sizes (ES=-0.98), supporting the FAST's ability to detect functional improvements over time.
Conclusions: The FAST is a valid and reliable instrument for assessing psychosocial functioning in adolescents and young adults with BPD.
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http://dx.doi.org/10.1016/j.euroneuro.2025.04.002 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFBMC Psychol
September 2025
Department of Psychology, Faculty of Arts and Humanities, King Abdulaziz University, Jeddah, Saudi Arabia.
Objectives/background: Prior studies have claimed that people engage in compulsive buying in an attempt to deal with stress. Nonetheless, not every stressed person engages in compulsive buying. It is therefore important to investigate the cognitive mechanisms underlying such behavior.
View Article and Find Full Text PDFSubst Abuse Treat Prev Policy
September 2025
Centre for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.
Background: Alcohol use disorder (AUD) is conceptualized as a dimensional phenomenon in the DSM-5, but electronic health records (EHRs) rely on binary AUD definitions according to the ICD-10. The present study classifies AUD severity levels using EHR data and tests whether increasing AUD severity levels are linked with increased comorbidity.
Methods: Billing data from two German statutory health insurance companies in Hamburg included n = 21,954 adults diagnosed with alcohol-specific conditions between 2017 and 2021.
BMC Psychol
September 2025
Center for Studies of Psychological Application, South China Normal University, 510631, Guangzhou, China.
With the persistence of difficult employment, a large number of college students feel anxious and nervous about job hunting. College students with different family economic status have various feelings and performances when faced with employment, possibly due to subjective social class differences. The present study investigated the employment confidence of 611 undergraduates in Chongqing, aimed to ascertain the overall employment confidence of Chinese college students, and tried to analyze how subjective social class works on the employment confidence of college students and its influencing mechanism.
View Article and Find Full Text PDFNutr J
September 2025
Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, 412 96, Sweden.
Background: Avenanthramides (AVAs) and Avenacosides (AVEs) are unique to oats (Avena Sativa) and may serve as biomarkers of oat intake. However, information regarding their validity as food intake biomarkers is missing. We aimed to investigate critical validation parameters such as half-lives, dose-response, matrix effects, relative bioavailability under single dose, and in relation to the abundance of Feacalibacterium prausnitzii, and under repeated dosing, to understand the potential applications of AVAs and AVEs as biomarkers of oat intake.
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