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Brugada syndrome (BrS) is an inherited disorder associated with a risk of ventricular fibrillation (VF) and sudden cardiac death (SCD) in a structurally normal heart mainly in young males, related to pathogenic variants in the gene. There are three electrocardiographic patterns in BrS that must be identified, being diagnostic only type 1 pattern (coved J-point elevation >2 mm with a negative T-wave in V1 to V3). However, other circumstances can lead to a type 1 Brugada-like ECG, such as atypical right bundle branch block, , arrhythmogenic right ventricular cardiomyopathy, acute coronary syndromes (occlusion of the left anterior descending artery or the conus branch of the right coronary artery), hypokalemia/hyperkalemia and cocaine poisoning, when present, these conditions are known as Brugada phenocopies, and it is imperative to rule out these conditions. We present the case of a young man with syncope with an initial suspected "normal" electrocardiogram with posterior development of type 1 Brugada pattern and an episode of non-sustained ventricular tachycardia.
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http://dx.doi.org/10.7759/cureus.82684 | DOI Listing |
JACC Case Rep
September 2025
Cardiovascular Diseases Section, Interdisciplinary Department of Medicine (DIM), University of Bari "Aldo Moro," Bari, Italy.
Background: Brugada syndrome (BrS) is a rare inherited arrhythmia disease carrying a variable risk of sudden cardiac death. Diagnosis requires the type 1 Brugada electrocardiographic pattern, which can either be spontaneous or induced by sodium channel-blocking drugs. Ranolazine is an antianginal drug acting on the late sodium current with emerging antiarrhythmic properties; no information is available on the safety of ranolazine use in patients with BrS.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2025
CERVO Brain Research Centre, Quebec City, QC, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, QC, Canada. Electronic address:
Brugada syndrome is a rare inherited cardiac arrhythmia disorder primarily characterized by ventricular fibrillation, which can lead to sudden cardiac death. It follows an autosomal dominant pattern of inheritance and is most associated with dysfunction of the cardiac sodium channel Nav1.5.
View Article and Find Full Text PDFCureus
July 2025
Private Practice, Humanis Dental Center, Perugia, ITA.
Brugada syndrome (BrS) is a rare inherited cardiac condition associated with a heightened risk of malignant arrhythmias, particularly during exposure to various pharmacological agents, including certain local anesthetics with sodium channel-blocking properties. This condition often generates significant concern among dental professionals, as the routine use of local anesthetics raises uncertainty about safety protocols and perceived medico-legal risks, frequently leading to patient refusal. The result is a silent yet systematic exclusion of these patients from standard pathways of care, with implications that extend beyond the clinical domain to encompass ethical, deontological, and social dimensions.
View Article and Find Full Text PDFJ Clin Med
August 2025
Cardiology Unit, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino", 98124 Messina, Italy.
Brugada syndrome (BrS) is a cardiac arrhythmic disorder associated with distinctive electrocardiographic (ECG) abnormalities and an increased risk of sudden cardiac death due to ventricular arrhythmias. While the classic BrS ECG pattern is a coved ST-segment elevation in the right precordial leads, a wide spectrum of atypical ECG presentations can mislead the diagnosis. This review discusses rare and under-recognized ECG findings associated with BrS, including its coexistence with right and left bundle branch block, alterations in peripheral leads and in the morphology of the QRS complex, as well as atrioventricular conduction abnormalities.
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