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| http://dx.doi.org/10.1016/j.jaad.2025.05.1397 | DOI Listing |
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Nutritional and Pharmacological Significance of Pomegranate (Punica granatum L): A Comprehensive Narrative Review.
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Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Pomegranate (Punica granatum L) is a rich source of bioactive compounds, including punicalagin, ellagic acid, anthocyanins, and urolithins, which contribute to its broad pharmacological potential. This review summarizes evidence from in vitro and in vivo experiments, as well as clinical studies, highlighting pomegranate's therapeutic effects in inflammation, metabolic disorders, cancer, cardiovascular disease, neurodegeneration, microbial infections, and skin conditions. Mechanistic insights show modulation of pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), alpha serine/threonine-protein kinase (AKT1), and nuclear factor erythroid 2-related factor 2 (Nrf2).
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School of the Environment, The University of Queensland, Brisbane, Queensland 4072, Australia.
As the global urban heat island (UHI) effect intensifies, understanding how UHI intensity responds to its influencing factors changes is critical for designing effective mitigation strategies. We focused on global megacities, shifted the UHI intensity assessment from physical indicators to human-related parameters, and then evaluated how human-centered UHI intensity responded to influencing factor change. We verified a significant discrepancy between traditional UHI intensity and human-centered UHI intensity worldwide, an average absolute difference of 1.
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University College London, London, United Kingdom.
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Center for Healthy Minds and Department of Counseling Psychology, University of Wisconsin-Madison, Madison, WI, United States.
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Randomized Controlled Trial of Impact of Mobile Health Technologies on Human Papillomavirus Vaccination Uptake in Mothers of Vaccine-Eligible Girls in Lagos, Nigeria (mHealth-HPVac).
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Department of Obstetrics and Gynaecology, Stanford University School of Medicine, Stanford, CA.
Purpose: Expanding high-risk human papillomavirus (HPV) vaccine coverage in resource-constrained settings is critical to bridging the cervical cancer gap and achieving the global action plan for elimination. Mobile health (mHealth) technology via short message services (SMS) has the potential to improve HPV vaccination uptake. The mHealth-HPVac study evaluated the effectiveness of mHealth interventions in increasing HPV vaccine uptake among mothers of unvaccinated girls aged 9-14 years in Lagos, Nigeria.
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