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Article Abstract
Purpose Of Review: The limitations of pathogen-directed therapies include growing antimicrobial resistance or the complete lack of any effective antimicrobial agents. This review highlights the potential for host-directed immunotherapies.
Recent Findings: This review provides a current status of host-directed immunotherapies to fight infectious diseases (HIFI), defining the concept and existing modalities. Drawing on large-scale viral studies - most of which are historical with limited recent research - the review highlights key lessons for its future clinical application.
Summary: HIFI represents a paradigm shift in infectious disease management, moving beyond pathogen-targeting to harnessing and modulating host immunity. This approach requires better mechanistic and pharmacologic understanding of existing modalities, development of newer agents based on tractable immunobiology, and robust clinical studies.
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| http://dx.doi.org/10.1097/QCO.0000000000001116 | DOI Listing |
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