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Renal cell carcinoma (RCC) metastasis to the gallbladder is exceedingly rare. A 60-year-old man with a history of RCC underwent cholecystectomy for incidental gallbladder polyps. Pathology confirmed metastatic RCC via immunohistochemistry staining. Despite surgery, bone lesions suggestive of metastasis emerged at the eight-month follow-up. This case underscores the importance of vigilance for atypical metastases in RCC survivors and the critical role of histopathology in avoiding misdiagnosis.
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http://dx.doi.org/10.7759/cureus.82614 | DOI Listing |
Acta Med Okayama
August 2025
Department of Thoracic Surgery, Japanese Red Cross Society Himeji Hospital.
An 80-year-old male underwent an extended cholecystectomy for node-positive gallbladder adenocarcinoma. Two weeks later, hemoptysis revealed a left hilar tumor obstructing the bronchus, which was diagnosed as adenocarcinoma. Three months post-cholecystectomy, a left upper pulmonary lobectomy was performed.
View Article and Find Full Text PDFTransl Oncol
August 2025
Department of Pathology, Shanghai University of Traditional Chinese Medicine Yueyang Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai, China. Electronic address:
Luteolin, 3',4',5,7-tetrahydroxyflavone, a natural flavonoid component found in various Chinese herbs such as Scutellaria barbata D. Don, honeysuckle, chrysanthemum, schizonepeta, and ajuga decumbens, exhibits potential for cancer prevention and therapy. This study elucidates the molecular mechanisms by which luteolin, an active constituent of Scutellaria barbata, inhibits invasion and metastasis of hepatocellular carcinoma (HCC) cell lines both in vitro and in vivo.
View Article and Find Full Text PDFFront Oncol
July 2025
Precision Pathological Diagnosis Center, Weifang People's Hospital (First Affiliated Hospital of Shandong Second Medical University), Weifang, Shandong, China.
Adenocarcinoma (AC) and neuroendocrine carcinoma (NEC) in the gallbladder originate from glandular epithelium and neuroendocrine cells, respectively. AC and NEC are called mixed AC-NEC (MANEC) when they occur in the same tumor. The present study presents the case of a 57-year-old female individual who was diagnosed with gallbladder space.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Surgery, Bucheon Sejong Hospital, Bucheon 14754, Republic of Korea.
Gallbladder cancer (GBC) is a lethal malignancy curable only by surgical resection in early stages (Tis, T1, T2). Significant controversy exists regarding the optimal extent of surgery. This review summarizes recent trends and evidence on surgical strategies for Tis, T1, and T2 GBC to guide practice and research.
View Article and Find Full Text PDFJ Cell Mol Med
August 2025
Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Gallbladder cancer (GBC) remains a challenging malignancy with a poor prognosis largely due to its highly metastatic nature and lack of effective treatment options. In this study, we investigated the role of N6-methyladenosine (m6A) modification and its regulatory factors, METTL3 and METTL14, in GBC. Our results showed that m6A levels as well as the expression of METTL3 and METTL14 were significantly downregulated in GBC tissues compared to normal gallbladder tissues.
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