98%
921
2 minutes
20
Manual segmentation of histopathological images is both resource-intensive and prone to human error, particularly when dealing with challenging tumor types like Glioblastoma (GBM), an aggressive and highly heterogeneous brain tumor. The fuzzy borders of GBM make it especially difficult to segment, requiring models with strong generalization capabilities to achieve reliable results. In this study, we leverage the Medical Open Network for Artificial Intelligence (MONAI) framework to segment GBM tissue from hematoxylin and eosin-stained Whole-Slide Images. MONAI performed comparably well to state-of-the-art AutoML tools on our in-house dataset, achieving a Dice score of 79%. These promising results highlight the potential for future research on public datasets.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3233/SHTI250279 | DOI Listing |
Forensic Sci Int
August 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Canada.
We report the forensic and clinicopathological spectrum of 14 postmortem cases involving the vertebral artery. In all cases, there was either pontocerebellar infarction (n = 8) or subarachnoid hemorrhage (n = 6). The underlying pathology of the vertebral artery was segmental mediolytic arteriopathy (n = 5), traumatic rupture of the arterial wall (n = 3), arterial dissection (n = 2), or atherosclerosis (n = 4).
View Article and Find Full Text PDFAcad Radiol
September 2025
In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (H.-C.K., S.-J.P.); Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan (S.-J.P.). Electronic address: sjpeng2
Rationale And Objectives: Computed tomography (CT) remains the primary modality for assessing renal tumors; however, tumor identification and segmentation rely heavily on manual interpretation by clinicians, which is time-consuming and subject to inter-observer variability. The heterogeneity of tumor appearance and indistinct margins further complicate accurate delineation, impacting histopathological classification, treatment planning, and prognostic assessment. There is a pressing clinical need for an automated segmentation tool to enhance diagnostic workflows and support clinical decision-making with results that are reliable, accurate, and reproducible.
View Article and Find Full Text PDFAnat Sci Int
September 2025
Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine, 30-1 Oyaguchi-Kami-Cho, Itabashi-Ku, Tokyo, 173-8610, Japan.
An aberrant right subclavian artery (ARSA) is a congenital vascular anomaly in which the right subclavian artery originates directly from the aortic arch distal to the left subclavian artery. Although often asymptomatic, ARSA can lead to clinical complications, such as dysphagia, upper respiratory issues, and vascular events. In this study, we examined the gross anatomical and histological characteristics of the ARSA based on three cadavers selected from a total of 7 ARSA cases identified among 3,158 specimens dissected between 1948 and 2024 at Nihon University School of Medicine (overall incidence: 0.
View Article and Find Full Text PDFClin Nucl Med
September 2025
Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
Background: Non-small cell lung cancer (NSCLC) is a complex disease characterized by diverse clinical, genetic, and histopathologic traits, necessitating personalized treatment approaches. While numerous biomarkers have been introduced for NSCLC prognostication, no single source of information can provide a comprehensive understanding of the disease. However, integrating biomarkers from multiple sources may offer a holistic view of the disease, enabling more accurate predictions.
View Article and Find Full Text PDFComput Biol Med
September 2025
London South Bank University, Department of Computer Science & Informatics, 103 Borough Rd, London, SE1 0AA, United Kingdom.
Delineating and classifying individual cells in microscopy tissue images is inherently challenging yet remains essential for advances in medical and neuroscientific research. In this work, we propose a new deep learning framework, CISCA, for automatic cell instance segmentation and classification in histological slices. At the core of CISCA is a network architecture featuring a lightweight U-Net with three heads in the decoder.
View Article and Find Full Text PDF