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The cosmetic use of botulinum toxin type-A (BTA) has expanded to include the "lip flip" procedure, which enhances lip contour and fullness without adding volume. This minimally invasive and cost-effective technique offers a favorable safety profile for patients seeking subtle lip enhancement. This review systematically examines the technique, clinical outcomes, and safety of the lip flip through neuromodulation with BTA. A comprehensive literature search was conducted using PubMed and Ovid, identifying 48 articles, of which seven met inclusion criteria detailing injection sites and dosages. The procedure typically involves injecting 4-6 units of BTA into the orbicularis oris muscle, resulting in consistent upper lip eversion and improved contour. Patients report high satisfaction and minimal downtime, with mild and transient side effects such as difficulty whistling or drinking through straws resolving within weeks.
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http://dx.doi.org/10.1007/s00403-025-04265-0 | DOI Listing |
Facial Plast Surg
June 2025
Department of Otolaryngology - Head & Neck Surgery, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania.
Neurotoxins and fillers have become increasingly popular for restoring age-related changes in the perioral region. This review examines their roles in optimizing perioral rejuvenation.The perioral region composes the lower third and middle three-fifths of the face.
View Article and Find Full Text PDFArch Dermatol Res
May 2025
Mohs Micrographic & Reconstructive Surgery, Epiphany Dermatology, Dallas, TX, USA.
The cosmetic use of botulinum toxin type-A (BTA) has expanded to include the "lip flip" procedure, which enhances lip contour and fullness without adding volume. This minimally invasive and cost-effective technique offers a favorable safety profile for patients seeking subtle lip enhancement. This review systematically examines the technique, clinical outcomes, and safety of the lip flip through neuromodulation with BTA.
View Article and Find Full Text PDFEur J Pharm Sci
June 2025
College of Life Sciences and Pharmacy, Hainan University, Haikou, Hainan, PR China; Department of Medical Laboratory, Hainan Cancer Hospital, Affiliated Cancer Hospital of Hainan Medical University, Haikou, Hainan, PR China; Hainan Tropical Cancer Research Institute, Haikou, Hainan, PR China. Electr
As the world's only commercially available paclitaxel liposome, Lipusu (Lip) has been clinically used in chemotherapy for >20 years, but the design concept of Lip remains largely unchanged since its initial development. Based on the study of Acetyl-CoA-carboxylase 1 (ACC1) in nasopharyngeal carcinoma (NPC), we proposed the concept of next-generation liposomes (NGL) utilizing lipid demand balance. In this study, we evaluated the feasibility of ACC1 and integrin αβ as NPC targets, and designed 10 conjugates of 5-tetradecyloxy-2-furoic acid (TOFA) and c(RGDfK) that can bind to Lip.
View Article and Find Full Text PDFJ Cosmet Dermatol
February 2025
Anne Burnett Marion School of Medicine, Texas Christian University, Fort Worth, Texas, USA.
Background: The lip augmentation market is projected to reach a value of 11.6 billion USD by 2030. Hyaluronic acid (HA) fillers are the most common type due to biocompatibility and reversibility.
View Article and Find Full Text PDFNat Biotechnol
October 2024
Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Methods to systematically monitor protein complex dynamics are needed. We introduce serial ultrafiltration combined with limited proteolysis-coupled mass spectrometry (FLiP-MS), a structural proteomics workflow that generates a library of peptide markers specific to changes in PPIs by probing differences in protease susceptibility between complex-bound and monomeric forms of proteins. The library includes markers mapping to protein-binding interfaces and markers reporting on structural changes that accompany PPI changes.
View Article and Find Full Text PDF