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Across natural and human-made systems, transition points mark sudden changes of order and are thus key to understanding overarching system features. Motivated by recent experimental observations, we here uncover an intriguing class of transitions in coupled oscillators, extreme synchronization transitions, from asynchronous disordered states to synchronous states with almost completely ordered phases. Whereas such a transition appears like discontinuous or explosive phase transitions, it exhibits markedly distinct features. First, the transition occurs already in finite systems of N units and so constitutes an intriguing bifurcation of multi-dimensional systems rather than a genuine phase transition that emerges in the thermodynamic limit N → ∞ only. Second, the synchronization order parameter jumps from moderate values of the order of N to values extremely close to 1, its theoretical maximum, immediately upon crossing a critical coupling strength. We analytically explain the mechanisms underlying such extreme transitions in coupled complexified Kuramoto oscillators. Extreme transitions may similarly occur across other systems of coupled oscillators as well as in certain percolation processes. In applications, their occurrence impacts our ability of ensuring or preventing strong forms of ordering, for instance in biological and engineered systems.
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http://dx.doi.org/10.1038/s41467-025-59729-8 | DOI Listing |
Prog Mol Biol Transl Sci
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Heidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany. Electronic address:
Climate change poses a growing threat to human health, increasing exposure to extreme environmental conditions. Wearable biosensors provide real-time monitoring of physiological responses to heat stress, including cardiovascular strain, thermoregulatory disruptions, sleep disturbances, and biomarkers of heat-related illnesses. These devices also assess behavioural adaptations, such as reduced physical activity, offering insights into physiological resilience and susceptibility.
View Article and Find Full Text PDFChem Sci
September 2025
Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Institute of Modern Optics and Centre of Single-Molecule Science, Nankai University Tianjin 300350 China
The keto-enol tautomerism, involving a reversible isomerization of the molecule, plays a critical role in organic synthesis, biological activity, and molecular-scale charge transport. It is therefore essential to manipulate the process of keto-enol tautomerism. Unlike typical ketones, β-diketones exist dominantly in the enol form and it is a great challenge to realize enol-keto tautomerism due to the formation of intramolecular hydrogen bonds in the enol form.
View Article and Find Full Text PDFCommun Earth Environ
September 2025
School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
Climate change is resulting in more extreme fire weather during major heatwaves. Across temperate Europe, shrub landscapes dominate the area burned, with the moisture content of fuels during these events determining the threat posed. Current controls on the moisture content of temperate fuel constituents and their response to future extreme heatwaves are not known.
View Article and Find Full Text PDFOncol Lett
November 2025
Department of Oncology, Nanjing Gaochun People's Hospital, Jiangsu, Nanjing 211300, P.R. China.
Triple-negative invasive lobular carcinoma (TN-ILC) is a rare and highly aggressive subtype of breast cancer. The development of gastric metastases in breast cancer is extremely rare and typically occurs several years after initial diagnosis. The present case report describes a 68-year-old postmenopausal female patient who presented with TN-ILC with gastric metastases at initial diagnosis.
View Article and Find Full Text PDFComput Biol Med
September 2025
Neuromorphic Computing Center, Neimark University, 6 Nartov St., Nizhny Novgorod, 603081, Russia; Department of Neurotechnology, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., Nizhny Novgorod, 603022, Russia; Baltic Center for Neurotechnology and Artificial Intelligence, Immanuel
During epileptic seizures, brain activity and connectivity undergo dramatic changes. Brain networks transition from a balanced resting state to a hyperactive and hypersynchronous state. However, the mechanisms driving these state transitions remain unclear.
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