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By integrating super-aligned carbon nanotube (SACNT) films with paraffin wax, an addressable optical valve composite array was created through screen printing and laser cutting. The temperature of the SACNT film can be controlled, which rapidly induces phase changes in the paraffin wax, leading to a swift change in optical transparency. The transmission spot exhibited significant differences, with a contrast degree reaching up to 0.65. At a paraffin wax surface density of 1.17 × 10 g mm, the rise and fall times of the transmitted optical signal across the 350-1100 nm spectrum were 155 ± 2 ms and 135 ± 11 ms, respectively, enabling rapid spatial light modulation. A prototype was fabricated, capable of dynamically displaying letters, with the crosstalk effect of the current being significantly mitigated in spatial light modulation. This rapid spatial light modulation prototype can be customized to any shape and size, and it can either be freestanding or mounted on any substrate. This innovation offers a new approach to spatial light modulation.
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http://dx.doi.org/10.1039/d5nh00007f | DOI Listing |
Nat Metab
September 2025
Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT, USA.
The essential cofactor coenzyme A (CoASH) and its thioester derivatives (acyl-CoAs) have pivotal roles in cellular metabolism. However, the mechanism by which different acyl-CoAs are accurately partitioned into different subcellular compartments to support site-specific reactions, and the physiological impact of such compartmentalization, remain poorly understood. Here, we report an optimized liquid chromatography-mass spectrometry-based pan-chain acyl-CoA extraction and profiling method that enables a robust detection of 33 cellular and 23 mitochondrial acyl-CoAs from cultured human cells.
View Article and Find Full Text PDFLight Sci Appl
September 2025
Laboratory of Quantum Information, University of Science and Technology of China, 230026, Hefei, China.
Quantum imaging with spatially entangled photons offers advantages such as enhanced spatial resolution, robustness against noise, and counterintuitive phenomena, while a biphoton spatial aberration generally degrades its performance. Biphoton aberration correction has been achieved by using classical beams to detect the aberration source or scanning the correction phase on biphotons if the source is unreachable. Here, a new method named position-correlated biphoton Shack-Hartmann wavefront sensing is introduced, where the phase pattern added on photon pairs with a strong position correlation is reconstructed from their position centroid distribution at the back focal plane of a microlens array.
View Article and Find Full Text PDFDiscov Nano
September 2025
Department of Rehabilitation Medicine, Rehabilitation Medical Center, Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Immunoelectron Microscopy (IEM) is a technique that combines specific immunolabeling with high-resolution electron microscopic imaging to achieve precise spatial localization of biomolecules at the subcellular scale (< 10 nm) by using high-electron-density markers such as colloidal gold and quantum dots. As a core tool for analyzing the distribution of proteins, organelle interactions, and localization of disease pathology markers, it has irreplaceable value, especially in synapse research, pathogen-host interaction mechanism, and tumor microenvironment analysis. According to the differences in labeling sequence and sample processing, the IEM technology system can be divided into two categories: the first is pre-embedding labeling, which optimizes the labeling efficiency through the pre-exposure of antigenic epitopes and is especially suitable for the detection of low-abundance and sensitive antigens; the second is post-embedding labeling, which relies on the low-temperature resin embedding (e.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Photoremovable protecting groups (PRPGs) enable precise spatiotemporal control over molecular release and functional activation. Recent advances have introduced wavelength-selective systems for sequential deprotection, broadening applications in drug delivery, material synthesis, and photopolymerization. In parallel, PRPGs play a crucial role in photobase generators (PBGs) and photoacid generators (PAGs), enabling oxygen-tolerant, spatially controlled polymerization and depolymerization through light-induced base and acid release.
View Article and Find Full Text PDFBiomater Sci
September 2025
Biotechnology Science and Engineering Program, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
B cells are critical components of the adaptive immune system that proliferate and differentiate within the secondary lymphoid organs upon recognition of antigens and engagement of T cells. Traditional two-dimensional (2D) cell cultures fall short of replicating the intricate structures and dynamic evolution of three-dimensional (3D) environments found in lymphoid organs, prompting the development of more physiologically pertinent models. Our approach employs -hexanoyl glycol chitosan (HGC) coated ultra-low attachment (ULA) lattice plates to cultivate a 3D co-culture of CD40L-expressing MS5 stromal cells and naïve B cells derived from the peripheral blood mononuclear cells (PBMCs) of healthy human donors.
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