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Background: Lymphedema, a chronic condition characterized by accumulation of lymph fluid due to malfunction of the lymphatic system, remains a significant clinical challenge despite advances in diagnosis and treatment. Given that lymphatic surgery is an important therapeutic option, the aim of the present study was to establish an expert consensus on recommendations for improving the surgical management of lymphedema.
Methods: This was an international consensus study involving a modified nominal group and Delphi process. During the World Symposium for Lymphedema Surgery in 2023, the steering group invited five experts to participate in a nominal group with the aim of drawing up a set of seven preliminary recommendations. These recommendations were then evaluated and revised by a panel of 31 international experts in a two-round Delphi process. The threshold for consensus was set at a minimum of 70% agreement among panelists.
Results: Consensus regarding the content of the seven recommendations was high (mean overall agreement of 79.6%). Agreement was highest for the recommendations concerning specific techniques of reconstructive surgery, measures for preventing lymphedema and its clinical assessment, and post-intervention follow-up protocols.
Conclusions: The consensus recommendations on the surgical management of lymphedema highlight the importance of preoperative preparation of patients and careful clinical assessment. Also recommended is the use of preventive surgical procedures, including the combination of reconstructive and reductive techniques, along with multidisciplinary monitoring and follow up. Although these guidelines hold promise, further studies are required to evaluate their implementation and explore their impact on patient health outcomes.
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http://dx.doi.org/10.1097/PRS.0000000000012201 | DOI Listing |
Exp Cell Res
September 2025
Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:
Promoting lymphatic vessel regeneration is an important method for repairing lymphedema. SOX18 can regulate lymphatic vessel development and plays a crucial role in promoting lymphatic vessel generation. This study aims to demonstrate the role of SOX18 in regulating lymphatic vessel regeneration for the repair of lymphedema and explore its related molecular mechanism.
View Article and Find Full Text PDFDisabil Rehabil
September 2025
Department of Rehabilitation Sciences and Physiotherapy, University of Leuven, Leuven, Belgium.
Purpose: This study aims to cross-culturally validate the Dutch version of the Lymphedema Symptom Intensity and Distress Survey-Head and Neck version 2.0 (LSIDS-H&N v2.0).
View Article and Find Full Text PDFMicrosurgery
September 2025
Division of Plastic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Genital lymphedema presents significant challenges in surgical management, with limited effective interventions. This case report explores the use of contrast-enhanced ultrasound (CEUS) with microbubble injection as an alternative adjunct technique for lymphatic mapping in lymphaticovenous anastomosis (LVA) surgery for genital lymphedema. A retrospective chart review approved by our institutional review board was performed for patients with genital lymphedema undergoing LVA surgery between 2020 and 2024.
View Article and Find Full Text PDFSurg Case Rep
August 2025
Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Introduction: Lymphedema is generally managed with conservative therapy. However, in cases of severe fibrosclerotic lymphedema, debulking surgery is required, although rarely. We present a case of massive lymphedema in the left calf complicated by severe skin fibrosclerosis that was successfully managed with debulking surgery.
View Article and Find Full Text PDFMicrosurgery
September 2025
Department of Plastic Surgery and Burns, Hospital del Trabajador, Santiago, Chile.
Background: When indocyanine green lymphography (ICG-L) fails to display a linear pattern, preoperative planning for lymphovenous anastomosis (LVA) becomes challenging. Given the anatomical symmetry of lymphatics in extremities, the healthy limb can serve as a template for the affected one. This study introduces an accessible technique that uses augmented reality (AR) to mirror the lymphatic anatomy of the unaffected limb onto the affected side to assist in surgical planning.
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