98%
921
2 minutes
20
Olfactory dysfunction (OD) is a common nasal disease, particularly prevalent among the elderly population, significantly impacting the affected individuals' quality of life. This review focuses on the influence of aging and chronic inflammation on olfactory dysfunction, presenting insights from both the peripheral and central olfactory systems. By exploring the molecular mechanisms and pathological changes underlying the occurrence of olfactory dysfunction in relation to age-related diseases and chronic inflammation conditions, we aim to provide a comprehensive theoretical foundation for further research and offer valuable insights for more effective treatment of olfactory dysfunction.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069206 | PMC |
http://dx.doi.org/10.1007/s00018-025-05637-5 | DOI Listing |
Psychogeriatrics
September 2025
Department of Psychiatry, The 4th People's Hospital of Ziyang, Ziyang Psychosis Hospital, Ziyang, China.
Background: Olfactory training (OT) has been proposed as a non-pharmacological intervention to improve cognitive functions and depressive symptomatology, but evidence remains fragmented.
Methods: In this study, we conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) comparing OT versus control in middle-aged and elderly adults. Four databases (PubMed, Cochrane Library, Web of Science, Embase) were systematically searched from database inception through June 2025.
Diabetes Obes Metab
September 2025
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, Denmark.
Background: Taste and smell disorders are more common in individuals with diabetes, particularly among those with low insulin sensitivity or central obesity. These disorders may affect glycaemic control by altering dietary habits. This study aimed to investigate self-reported taste and smell dysfunction in individuals with diabetes and explore associations with clinical and behavioural factors.
View Article and Find Full Text PDFMov Disord Clin Pract
September 2025
Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Background: Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.
Objectives: We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).
Methods: In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders.
Chem Senses
September 2025
Institute of Psychology, University of Wroclaw, Wroclaw, Poland.
Olfactory training (OT), a structured exposure to odors, is commonly used by otorhinolaryngologists to treat olfactory dysfunction. However, OT has been shown to improve cognition of people with cognitive or olfactory impairments and slow the age-related cognitive decline. This study investigated whether OT could enhance cognitive functions in older adults with an intact sense of smell, compared to younger adults.
View Article and Find Full Text PDFFront Public Health
September 2025
Department of Family and Community Medicine, Penn State University College of Medicine, Hershey, PA, United States.
Background: The World Health Organization recommends at-home management of mild COVID-19. While our preliminary evaluation provided evidence for saline nasal irrigation (SNI) and gargling in COVID-19, an update and risk-benefit assessment for self-care in Omicron infection is warranted, from treatment and preparedness perspectives, as new SARS-CoV-2 variants continuously emerge, while symptoms overlap with those of common colds and other upper respiratory tract infections.
Methods: Systematic literature searches for preclinical and clinical studies involving Omicron infection and saline, bias assessment, and review of outcomes (benefits, risks).