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Large Language Models (LLMs) have shown remarkable potential in various fields. This study explores their application in solving multi-objective combinatorial optimization problems-surgery scheduling problem. Traditional multi-objective optimization algorithms, such as the Non-dominated Sorting Genetic Algorithm II (NSGA-II), often require domain expertise for designing precise operators. Here, we propose LLM-NSGA, where LLMs act as evolutionary optimizers, performing selection, crossover, and mutation operations. Results show that for 40 cases, LLMs can independently generate high-quality solutions from prompts. As problem size increases, LLM-NSGA outperformed traditional approaches like NSGA-II and MOEA/D, achieving average improvements of 5.39 %, 80 %, and 0.42 % in three objectives. While LLM-NSGA provided similar results to EoH, another LLM-based method, it outperformed EoH in overall resource allocation. Additionally, we applied LLMs for hyperparameter optimization, comparing them with Bayesian Optimization and Ant Colony Optimization (ACO). LLMs reduced runtime by an average of 23.68 %, and their generated parameters, validated with NSGA-II, produced better surgery scheduling solutions. This demonstrates that LLMs can not only help traditional algorithms find better solutions but also optimize their parameters efficiently.
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http://dx.doi.org/10.1016/j.artmed.2025.103151 | DOI Listing |
Clin Transplant
September 2025
Avera Medical Group Transplant & Liver Surgery, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, USA.
Background: In the United States, a severe organ shortage precipitates an extensive transplant waitlist. Living donor kidneys are functionally superior to those from deceased donors and offer an alternative to close the supply-demand gap.
Methods: A retrospective review of 2147 patients who self-referred to begin the living kidney donation workup process at our center between June 1, 2012, and October 1, 2023 was conducted with subsequent statistical analysis of gathered data.
Ann Afr Med
September 2025
Department of Anaesthesiology, Kasturba Medical College Mangalore Manipal Academy of Higher Education, Manipal, India.
Background: Regional anesthesia techniques, such as unilateral spinal anesthesia and peripheral nerve blocks, are essential components of multimodal analgesia. Nonetheless, "rebound pain," an abrupt increase in nociceptive intensity following the cessation of the block, is inadequately defined and may compromise patient satisfaction and functional recovery.
Aims And Objectives: This study aimed to compare postoperative pain profiles, the incidence of rebound pain, and patient satisfaction following popliteal sciatic nerve block versus unilateral spinal anesthesia in elective foot surgeries.
Ann Surg Oncol
September 2025
Surgical Oncology, The Institute for Cancer Care, Mercy Medical Center, Baltimore, MD, USA.
Introduction: The optimal surveillance for mucinous appendix cancer (MAC) after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) remains unclear. We identified postoperative periods reflecting significant changes in recurrence probability.
Methods: A prospective database (1998-2024) of patients with stage IV MAC with low-grade (LGMCP), high-grade (HGMCP), and signet-ring cell (SRC) histology treated with initial complete (CC-0/1) CRS/HIPEC was analyzed.
Dis Colon Rectum
September 2025
Department of Surgery, Oregon Health & Science University, Portland, Oregon.
Background: Anal squamous cell cancer incidence has risen 2.2% each year over the past decade. Current screening includes anal cytology and high-resolution anoscopy but is burdened with sampling error and patient discomfort.
View Article and Find Full Text PDFActa Anaesthesiol Scand
October 2025
Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Introduction: Electronic health records can be used to create high-quality databases if data are structured and well-registered, which is the case for most perioperative data in the Capital and Zealand Regions of Denmark. We present the purpose and development of the AI and Automation in Anaesthesia (TRIPLE-A) database-a platform designed for epidemiology, prediction, quality control, and automated research data collection.
Methods: Data collection from the electronic medical record (EPIC Systems Corporation, WI, USA) was approved by the Capital Region, Denmark, and ethical approval was waived.