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Recent research reported an association between pediatric Restless Leg Syndrome (RLS) and psychiatric disorders, in particular attention-deficit hyperactivity disorder in which shared symptoms, such as restlessness and difficulty concentrating, can make differential diagnosis challenging. Comorbidities with depression and anxiety, present in adults, have to be considered in children. Behavioral and psychosomatic disorders and autism can be associated with RLS. Both neurobiologic mechanisms and clinical implication could explain the several comorbidities. In clinical practice, pediatric RLS patients should be evaluated for the presence of psychiatric disorders to tailor multidisciplinary intervention and integrated treatment.
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http://dx.doi.org/10.1016/j.jsmc.2025.02.004 | DOI Listing |
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
Front Neurol
August 2025
Unit of Child Neurology and Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Introduction: Restless Legs Syndrome (RLS), known as Willis-Ekbom disease, is a common neurological condition that often goes undiagnosed, especially in children. Characterized by an irresistible urge to move the legs, it is typically more pronounced in the evening and at rest. Growing Pains (GP), common in childhood and associated with migraine, present apparently overlapping symptoms with RLS, making it sometimes difficult to distinguish between the two.
View Article and Find Full Text PDFMed Oncol
August 2025
Department of Interventional Radiology & Vascular Anomalies, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No.9, Jinsui road, Tianhe District, Guangzhou, 510627, Guangdong, China.
Background: Retinoblastoma is an intraocular malignancy with limited therapeutic options, imposing a severe health burden on young patients. Wedelolactone (WDL), a natural product from E. prostrata, possesses an anti-retinoblastoma activity, with the underlying regulatory mechanism remaining unknown.
View Article and Find Full Text PDFCureus
July 2025
Pediatric Otolaryngology, Oklahoma State University Center for Health Sciences, Tulsa, USA.
Background Sleep-disordered breathing (SDB) and attention-deficit/hyperactivity disorder (ADHD) symptoms frequently co-occur in children and may be exacerbated by nasal obstruction. While adenotonsillar hypertrophy has been extensively studied, the role of inferior turbinate hypertrophy remains underrecognized. Objective To evaluate the effects of inferior turbinate reduction (ITR) on nasal breathing, SDB symptoms, and ADHD-type behaviors in pediatric patients.
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