New ecdysteroids with anticomplementary activity from roots of (L.) holub.

Nat Prod Res

Chemical R&D, School of Pharmaceutical Sciences, Hebei Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, China.

Published: May 2025


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Article Abstract

Phytochemical investigation on roots extract of (L.) Holub led to the isolation of two novel ecdysteroids, 11-hydroxy-25-inokosterone (1) and 11-hydroxy-24, 25 -amarasterone A (2), along with 20 known constituents. The structures of novel compounds were confirmed by NMR and ECD spectroscopy. Compounds and exhibited anticomplementary activity with classical pathway, their CH values were 138.4 ± 0.07 µg·mL and 158.3 ± 0.09 µg·mL, respectively.

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http://dx.doi.org/10.1080/14786419.2025.2502855DOI Listing

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