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http://dx.doi.org/10.1001/jamaoncol.2025.0620 | DOI Listing |
Ann Surg Oncol
September 2025
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Crit Rev Toxicol
September 2025
Laboratório de Reprodução e Toxicologia (Laretox), Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Malathion and diazinon are pesticides widely used in agriculture as well as for domestic and veterinary purposes to control pests, such as scale insects, aphids, and fleas. However, these compounds may have harmful effects on the female genital system in humans and animals. This study conducted a systematic review of the scientific literature on the female reproductive effects in humans and rodents exposed to malathion or diazinon.
View Article and Find Full Text PDFFront Immunol
September 2025
Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Introduction: Although Interleukin (IL)-6-type cytokine signaling is critical for maintaining the body's homeostasis, aberrant signaling has been observed in numerous diseases including autoimmunity and cancer. Currently, all approved biologics that inhibit IL-6-type cytokines specifically target the key pro-inflammatory mediator IL-6 or its receptor (IL6R). Historically, direct inhibition of glycoprotein 130 (gp130)-the shared transmembrane receptor for IL-6-type cytokines-was avoided due to concerns that broad suppression might cause more harm than benefit.
View Article and Find Full Text PDFJ Trace Elem Med Biol
August 2025
Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, United States.
Ranked as a "top 10 cause of death", chronic liver disease accounts for millions of deaths annually. The prevalence of the most prominent liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), has doubled over the past 20 years and continues to rise. Growing in parallel are environmental chemical exposures, emergingas key risk factors for liver disease.
View Article and Find Full Text PDFJ Thorac Cardiovasc Surg
August 2025
Department of Thoracic Surgery, Affiliated Huadong Hospital, Fudan University, Shanghai, China.