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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166293PMC
http://dx.doi.org/10.1093/ibd/izaf084DOI Listing

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Background: The patient experience after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) remains poorly defined, resulting in heterogeneity in clinical assessments and research. We performed a qualitative study to better understand the experience of patients after IPAA for UC, with a focus on the symptoms experienced by patients and the resultant effects on quality of life (QoL).

Methods: We conducted semi-structured focus groups among patients who had undergone IPAA for UC.

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Article Synopsis
  • - The study examined the use of the modified pouchitis disease activity index (mPDAI) to assess symptoms and endoscopic findings among different pouchitis phenotypes in inflammatory bowel disease (IBD).
  • - A total of 103 IBD patients were analyzed, revealing that patients with normal pouches had a median mPDAI of 0, while those with cuffitis had the highest median score of 4.0, indicating more severe symptoms.
  • - The findings suggested that the mPDAI may have limited effectiveness in differentiating between various inflammatory phenotypes, prompting the need for further research to identify which symptoms should be monitored.
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Functional Disorders of the Ileal-Anal Pouch: A Systematic Review.

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June 2024

Global Center for Integrated Colorectal Surgery and IBD Interventional Endoscopy, Columbia University Medical Center, New York, New York.

Background: The IPAA is a boon to patients needing proctocolectomy but maintains per anal function through anatomic and physiologic compromises. The state of pouch function is hard to define because pouch anatomy is not normal and pouch physiology is a distortion of normal defecation. Patients with pouches develop multiple symptoms: some are expected, some are disease related, and some are the result of surgical complications.

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Background: Our understanding of outcomes after proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is largely based on analyses of selected populations. We created a state-level registry to evaluate the epidemiology of IPAA surgery and pouch-related outcomes across the major healthcare systems performing these surgeries in our state.

Methods: We created a retrospective cohort of all patients undergoing restorative proctocolectomy with IPAA for UC at 1 of 4 centers between January 1, 2018, and December 31, 2020.

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