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Background: The backflow phenomenon represents a challenge when using needleless connectors. This bench study investigated backflow volume ( the quantifiable amount of backflow) into a long peripheral catheter by evaluating needleless connectors with four technologies (positive, negative, neutral, and anti-reflux) and three clamping sequences.
Methods: Four different connectors with varying displacement technologies were tested to assess backflow volume using the manufacturer's recommended clamping sequences and a sequence in which the clamp was not foreseen. A high-fidelity experimental model was used. Neutral and anti-reflux needleless connectors were evaluated with varying clamping sequences. The backflow volume values are presented as median and interquartile range.
Results: Backflow was observed in all cases, with a wide range of results: the lowest backflow volume was recorded with the anti-reflux connector, while the highest was recorded with the negative connector, both when no clamp was used. The clamp significantly reduced backflow volume in negative and positive connectors, while no differences were noted between neutral and anti-reflux types across the sequences.
Conclusion: Using only needleless connectors in long peripheral catheters does not prevent the backflow phenomenon. Using clamps significantly reduced the backflow volume in needleless connectors with positive and negative displacement. Neutral and anti-reflux connectors perform similarly in the clamping sequences with and without clamps.
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http://dx.doi.org/10.1177/11297298251336805 | DOI Listing |
Microsurgery
September 2025
Department of Plastic Surgery and Burns, Hospital del Trabajador, Santiago, Chile.
Background: When indocyanine green lymphography (ICG-L) fails to display a linear pattern, preoperative planning for lymphovenous anastomosis (LVA) becomes challenging. Given the anatomical symmetry of lymphatics in extremities, the healthy limb can serve as a template for the affected one. This study introduces an accessible technique that uses augmented reality (AR) to mirror the lymphatic anatomy of the unaffected limb onto the affected side to assist in surgical planning.
View Article and Find Full Text PDFJ Neurosurg Pediatr
August 2025
1Department of Neurosurgery, UMass Chan Medical School.
Objective: Stereotactic gene therapy in children is challenging due to the fragility of the infant skull and long hours of infusion. The thalamus, an integrative hub for the entire cortex, has been shown to facilitate widespread gene/protein delivery via axonal transport. The aim of this study was to evaluate the safety and accuracy of bilateral thalamic convection-enhanced delivery (CED) of adeno-associated virus (AAV) vectors for GM2 gangliosidoses in children and to assess outcomes based on post-infusion imaging.
View Article and Find Full Text PDFInt J Med Sci
August 2025
Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Lymphovenous anastomosis (LVA) is an effective treatment for restoring lymphatic function in patients with lymphedema. This study aimed to assess the predictive value of preoperative lymphoscintigraphy in female patients undergoing LVA for lower extremity lymphedema (LEL). Female patients with unilateral LEL who underwent preoperative lymphoscintigraphy followed by LVA were retrospectively examined.
View Article and Find Full Text PDFUltrason Sonochem
September 2025
State Key Laboratory of Hydroscience and Engineering, Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory of CO(2) Utilization and Reduction Technology, Tsinghua University, Beijing 100084, China. Electronic address:
Hydrodynamic cavitation (HC) surge accompanied by strong swirl is widely present in fluid machinery and has become a hot topic in many engineering fields. This paper employed a two-way coupling Eulerian-Lagrangian multiscale cavitation modeling method to investigate the unsteady characteristics of HC surge under two typical conditions in a diffuser with swirling flow. Compared with the available experimental data, the quasi-periodic growth, shedding and fragmentation of HC surge into discrete bubbles are well reproduced by the multiscale cavitation modeling method.
View Article and Find Full Text PDFJ Vasc Access
May 2025
Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
Background: Needle-free connectors (NFCs) are closure systems for vascular catheters largely used because effectively reduce needlestick incidents. They are classified based on their impact on the fluid column within the catheter as (fluid displacement into the vein), (fluid displacement back from the vein into the catheter), (minimal displacement), or (equipped with additional anti-reflux valve). Each category has specific usage and clamping procedures.
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