98%
921
2 minutes
20
Background: Atlas fractures represent 25% of craniocervical injuries, most common in elders. Unstable first cervical vertebra fractures with lateral mass displacement require surgical fixation. Options include atlantoaxial fusion (AAF) or occiput-cervical fusion (OCF), each have their respective merits and detractors. Here, we compare the clinical and neurological outcomes of patients with unstable atlas fractures treated with AAF and OCF.
Methods: A retrospective review of patients with unstable atlas fractures that underwent either AAF or OCF between 2005 and 2023 was performed. Demographics, clinical characteristics, radiographic parameters, and outcomes were collected. Cervical sagittal balance was measured by O-second cervical vertebra (C2 or axis) angle, C2-7 lordosis, and C2-7 sagittal vertical axis (SVA).
Results: Forty-four patients with unstable atlas fractures were included (25 underwent AAF and 19 OCF). The median age was 73 years, and 52% were male. Demographics, mechanism of injury, and other clinical characteristics were similar. Landell's type 2 atlas fractures and lateral mass displacement were significantly in the OCF group. Median number of levels was significantly greater in the OCF group (3 vs. 2 in AAF, P=<0.001). C2-7 lordosis was less in OCF versus AAF (P = 0.045). SVA was less in the AAF group versus OCF (P = 0.044). Cervical SVA was decreased 4.5 mm in average in the AAF group versus 5.2 mm increase in OCF (P = 0.040). There were no significant differences in the rates of postoperative complication, surgical revision, or neurologic function.
Conclusions: OCF results in significant loss of lordosis and increase in cervical SVA relative to AAF, which may impact long-term quality of life and disability not directly measured in this study.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.wneu.2025.124024 | DOI Listing |
J Mech Behav Biomed Mater
September 2025
Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Osteoporosis constitutes a significant global health concern, however the development of novel treatments is challenging due to the limited cost-effectiveness and ethical concerns inherent to placebo-controlled clinical trials. Computational approaches are emerging as alternatives for the development and assessment of biomedical interventions. The aim of this study was to evaluate the ability of an In Silico trial technology (BoneStrength) to predict hip fracture incidence by implementing a novel approach designed to reproduce the phenomenology of falls as reported in clinical data, and by testing its accuracy in three virtual cohorts characterised by different risk profiles.
View Article and Find Full Text PDFSpine (Phila Pa 1976)
August 2025
Department of Neurosurgery, Austin Health and Cabrini Health, Melbourne, Victoria, Australia.
Study Design: Modified Delphi consensus survey.
Objective: To survey expert opinion on postoperative return-to-sport (RTS) decisions in athletes requiring cervical spine surgery.
Summary Of Background Data: Postoperative sport participation recommendations for athletes requiring cervical spine surgery are lacking, and management of these athletes remains challenging.
Afr Health Sci
June 2025
Department of Orthopedic Surgery, The First Hospital of Linping District, Hangzhou, 311000, Hangzhou, China.
Objective: To investigate the effect of anterior decompression with bone graft and internal fixation for dislocation of lower cervical vertebra, and to analyze the influencing factors of early postoperative complications.
Methods: The retrospective study included 90 patients with lower cervical fractures and dislocations who received anterior decompression and internal fixation in our hospital from November 2018 to October 2021. Postoperative indexes, therapeutic effects, postoperative recovery of cervical and spinal functions and complications were observed.
BMC Musculoskelet Disord
August 2025
Department of Orthopaedics and Traumatology, Giresun University, School of Medicine, Giresun, 28100, Turkey.
Background: Hip fractures are a significant public health issue among the elderly. While early surgical intervention's effects on morbidity are well-documented, the impact of delayed surgery on mortality and morbidity is less understood. This study aims to examine the medium-term morbidity and mortality in patients who underwent delayed surgery with an average preoperative waiting period of 14 days.
View Article and Find Full Text PDFCell Commun Signal
August 2025
Department of Pharmacology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058, China.
Type 2 diabetes mellitus (T2DM) is associated with an elevated fracture risk and impaired healing, but the periosteum's role in delayed repair remains unclear. In db/db mice, both trabecular and cortical bone mass were reduced, with single-cell RNA sequencing revealing downregulation of the Wnt pathway in osteogenic periosteal cells, which is critical for maintaining cortical bone. Transcriptomic analysis of periosteal cells from humans with T2DM further underscored the evolutionary conservation of osteogenic properties.
View Article and Find Full Text PDF