Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Wheat germ oil (WGO), derived from the nutrient-dense germ of wheat kernels, is a functional bioactive product, known for its rich composition of essential fatty acids, sterols, tocopherols, and polyphenols. This study aimed to comprehensively profile the molecular and therapeutic properties of WGO, focusing on its antioxidant, cytotoxic, and anti-inflammatory activity. Using advanced analytical techniques such as gas chromatography-mass spectrometry (GC-MS), Fourier Transform Infrared (FTIR) spectroscopy, and fluorescence analysis, WGO was shown to contain high levels of linoleic acid (45.3%), squalene (2.52 g/100 g), and polyphenols. WGO displayed selective cytotoxicity, inhibiting cancer cells' viability in melanoma, prostate, and colorectal cancer cell lines, but not normal cells, highlighting its chemoprevention potential. Furthermore, WGO significantly reduced LPS-induced nitric oxide and IL-6 production in macrophages, with effects plateauing at higher doses. The 3D fluorescence spectra showed a significant decrease in fluorescence intensity when human serum albumin interacted with the WGO polyphenol fraction, indicating a strong binding affinity and stable complex formation. These findings emphasize the nutritional and therapeutic potential of WGO as a natural bioactive agent, warranting further mechanistic investigation and broader applications in health and disease management.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12025205 | PMC |
| http://dx.doi.org/10.3390/biom15040464 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine.
PLoS One
September 2025
Nutrition Innovation Center, Standard Process Inc., Kannapolis, North Carolina, United States of America.
Polyamines (PAs), including spermidine, spermine and their precursor, putrescine, are ubiquitous molecules that are vital for a variety of physiological processes. Recently, PAs gained research attention because of their roles in promoting longevity and preventing age-related diseases. Circulating and tissue levels of PAs appear to decline with age, while higher intake of PAs in humans is correlated with better health during aging.
View Article and Find Full Text PDFFunctional inhibition of wheat germ agglutinin by glycodendrimers: Interplay of affinity, architecture, and temperature.
Carbohydr Res
September 2025
Area for Molecular Function, Division of Material Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama, 338-8570, Japan; Medical Innovation Research Unit (MiU), Advanced Institute of Innovative Technology (AIIT), Saitama University, Sakura, Saitama, 338-8570, Japa
Multivalent interactions between lectins and glycans are crucial for biological recognition; however, predicting functional inhibition based on binding affinity remains challenging. Herein, we investigated a series of structurally defined N-acetylglucosamine (GlcNAc)-functionalized dendrimers (1a-1c and 2a-2c) to examine how spatial orientation and temperature influenced the inhibition of wheat germ agglutinin (WGA). Using enzyme-linked lectin assays (ELLAs), we observed biphasic inhibition profiles for all the dendrimers, characterized by an initial enhancement of WGA binding at low concentrations, followed by effective inhibition at higher concentrations.
View Article and Find Full Text PDFAdropin as a therapeutic candidate for HFpEF: evidence of oxidative stress mitigation via Nrf2/HO-1 signaling.
Lipids Health Dis
September 2025
Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Background: Heart failure with preserved ejection fraction (HFpEF), which accounts for more than half of all heart failure cases worldwide, has emerged as a major public health challenge characterized by substantial morbidity and mortality rates. As adropin is a key regulator of cardiovascular and metabolic homeostasis, this study investigated its therapeutic effects against HFpEF pathogenesis.
Methods: C57BL/6 mice were fed a high-fat diet (60% fat-derived calories) with NG-nitro-L-arginine methyl ester (L-NAME, 0.
Effect of particle size variation of stabilized wheat germ on dough processing characteristics and steamed bread quality.
Food Chem X
August 2025
Associated Discipline Key Laboratory of Whole Grain Nutrition and High-Value Utilization, Anhui Science and Technology University, 9 Donghua Road, Fengyang, 233100, China.
Wheat germ is a by-product of wheat flour milling and processing, and is valued for being the nutrient-rich center of wheat grains. In this study, hot air-stabilized wheat germ with five different particle sizes (coarse, medium, fine, ultrafine, and very fine) was prepared and mixed with wheat flour (WF) in a ratio of 8:92. The study focused on the effect of particle size of stabilized wheat germ on the thermomechanical, dynamic rheological, and fermentation properties of wheat flour and the quality of steamed bread.
View Article and Find Full Text PDFEx vivo liquid core fiber photometry with high-resolution 3D printing.
Sens Actuators Rep
December 2024
Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA.
High resolution 3D printing emerges as an alternative to microfabrication due to its fine resolution along with one-step manufacturing. Thus, it is broadly used in many fields, such as biological and chemical applications. We introduce such a technique to the design of the optofluidic probe by integrating optics and microfluidics as an ex vivo liquid core fiber photometry.
View Article and Find Full Text PDF