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The gene has been shown to control development and pathogenicity in the plant necrotroph . We have identified the orthologous gene in two of the species complex; it maps to chromosome 7 in the core genome of the . It encodes a protein with two distinct domains, a GAL4-like Zn(II)2Cys6 binuclear cluster DNA-binding domain and an acetyltransferase domain, as previously shown in . Null mutants were generated in both ( and ), and the phenotypes exhibited during in culture growth and plant colonization were analyzed. The results obtained demonstrate that this virulence factor is required for complete colonization of the plant host stem vascular tissue and full virulence in but not for the initial stages of root colonization. In addition, null mutants showed a severe alteration in the formation of aerial mycelia and a drastic reduction of sporulation. These observations are consistent with a master role of FoG4MAT in the gene regulation of different processes crucial for normal development and full disease induction in the plant host.
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http://dx.doi.org/10.1094/PHYTO-02-25-0069-R | DOI Listing |
Microbiol Spectr
September 2025
International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Enterotoxigenic (ETEC), a leading cause of diarrhea, is defined by heat-stable (ST) and/or heat-labile (LT) toxins and associated colonization factors (CFs). However, there is still a knowledge gap in understanding ETEC's evolution, particularly in endemic regions like Bangladesh. This study investigates the genomic attributes contributing to the rise of ETEC-associated diarrhea in Bangladesh during 2022-2023.
View Article and Find Full Text PDFmBio
September 2025
Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
Unlabelled: There is a considerable interest in the association between and colorectal cancer (CRC). Recently, it was suggested that this association is valid only for a distinct clade of ( C2) and that strains belonging to another clade ( C1) are only associated with the oral cavity. It was further suggested that this made C1 a natural comparator when looking for candidate genes associated with the pathogenicity of C2.
View Article and Find Full Text PDFJ Virol
September 2025
Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Unlabelled: Oropouche fever is a debilitating disease caused by Oropouche virus (OROV), an arthropod-borne member of the Peribunyaviridae family. Despite its public health significance, the molecular mechanisms driving OROV pathogenesis remain poorly understood. In other bunyaviruses, the nonstructural NSs protein encoded by the small (S) genome segment acts as a major virulence factor.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
Punicalagin, a polyphenolic compound extracted from pomegranate peel, has received increasing attention in recent years due to its antibacterial and antiviral properties. Punicalagin is capable of inhibiting bacterial growth at sub-inhibitory concentrations by affecting cell membrane formation, disrupting membrane integrity, altering cell permeability, affecting efflux pumps, interfering with quorum sensing and influencing virulence factors. Additionally, punicalagin inhibits viruses by modulating enzyme activity, interacting with viral surface proteins, affecting gene expression, blocking viral attachment, disrupting virus receptor interaction and inhibiting viral replication.
View Article and Find Full Text PDFJ Oral Microbiol
September 2025
Department of Pediatric Dentistry, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Background: The neonatal period is critical for oral microbiome establishment, but temporal patterns in preterm newborns remain unclear. This study examined longitudinal microbiome changes in full-term and preterm newborns and assessed perinatal and clinical influences.
Methods: Oral swabs were collected from 98 newborns (23 full-term, 75 preterm).