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Guidelines for the management of lower leg ulcers/varicose veins, third edition is a fully revised guideline drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in a systematic and transparent manner with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. In the four clinical questions with meta-analyses, ultrasonography, compression therapy, surgical therapy, and sclerotherapy were weakly recommended in the treatment of lower leg ulcers/varicose veins. General information on diagnosis, prevention, assessment, and unconventional treatment of lower leg ulcers/varicose veins was also provided.
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http://dx.doi.org/10.1111/1346-8138.17746 | DOI Listing |
J Neuromuscul Dis
September 2025
Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Background: Electrical impedance myography (EIM) has been proposed as an efficient, non-invasive biomarker of muscle composition in facioscapulohumeral muscular dystrophy (FSHD).
Objective: We investigate whether EIM parameters are associated with muscle structure measured by magnetic resonance imaging (MRI), muscle histology, and transcriptomic analysis as well as strength at the individual leg muscle level.
Methods: We performed a multi-center cross-sectional study enrolling 33 patients with FSHD.
Cureus
August 2025
Dermatology, Centro Medico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Mexico City, MEX.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is an uncommon and aggressive subtype of cutaneous B-cell lymphoma, typically affecting elderly women and predominantly involving the lower extremities. Its diagnosis relies on immunohistochemical profiling and clinical presentation. We report a rare case of a 45-year-old male presenting initially with scalp and supraciliary plaques.
View Article and Find Full Text PDFCureus
August 2025
Physical Medicine and Rehabilitation, Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, MAR.
This case report describes the functional outcomes of a proprioceptive rehabilitation protocol for primary prevention in a 31-year-old patient with L5-S1 radiculopathy sequelae confirmed by electroneuromyography and associated ankle proprioceptive deficit. The patient underwent a seven-week proprioceptive rehabilitation protocol comprising 10 supervised sessions, with a six-month follow-up period. Assessment tools included the Foot and Ankle Ability Measure (FAAM), the single-leg balance test with eyes closed, and the visual analog scale (VAS) for perceived stability.
View Article and Find Full Text PDFCureus
August 2025
General Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, GBR.
Diabetes mellitus is a metabolic condition leading to elevated blood glucose levels due to insulin deficiency, insulin resistance, or a combination of both. Chronically raised blood glucose levels can lead to a broad variety of microvascular and macrovascular complications. Neurological disorders are a common manifestation of diabetes mellitus, and poorly controlled diabetes mellitus frequently causes peripheral sensorimotor polyneuropathy and autonomic neuropathy.
View Article and Find Full Text PDFProg Rehabil Med
September 2025
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Objectives: : This study aimed to assess the qualitative effects of locomotion training (LT) on articular cartilage using magnetic resonance imaging T1ρ mapping.
Methods: : Fifteen patients with early knee osteoarthritis participated in the study. They performed a series of exercises, including one-leg stands, squats, heel raises, and front lunges, on a daily basis for 12 weeks.