Successful Treatment of Median Arcuate Ligament Syndrome in the Hybrid Operating Room: A Report of Four Cases.

Median arcuate ligament syndrome (MALS) is a rare disease characterized by abdominal pain attributed to the compression of the celiac trunk by the median arcuate ligament (MAL). In this study, we describe four patients with MALS who were successfully treated using surgical dissection of the MAL in a hybrid operating room that allowed intraoperative angiography. All four patients described in this report experienced abdominal pain.

Durvalumab induced immune-related agranulocytosis after conversion surgery in a patient with intrahepatic cholangiocarcinoma: a case report.

We report a rare hematological immune-related adverse event (irAE) induced by durvalumab, an immune checkpoint inhibitor, after conversion surgery in a patient with intrahepatic cholangiocarcinoma (ICC). A 72-year-old male was admitted for recurrent ICC treatment in the posterior sector. The primary treatment chosen was systemic chemotherapy with durvalumab combined with gemcitabine and cisplatin.

Outcomes of Liver Transplantation Among Patients Diagnosed With Acute-on-Chronic Liver Failure: A Single-Center Experience.

Background: Acute-on-chronic liver failure (ACLF) describes the rapid deterioration of liver function triggered by factors including alcohol consumption, infection(s), and exacerbation(s) of chronic liver disease, and is characterized by a persistent "cytokine storm." While liver transplantation is the most effective treatment, comprehensive data regarding patient outcomes are limited.

Methods: Clinical data from 187 patients, who underwent liver transplantation (excluding re-transplantations and acute liver failure) between 2009 and 2023, were analyzed in accordance with Japan's ACLF diagnostic criteria.

A Challenging Case of Wild-Type Transthyretin Amyloidosis (ATTR) Amyloidosis Treated With Cardiac Resynchronization Therapy.

Wild-type transthyretin amyloidosis (ATTRwt) is an age-associated systemic disorder characterized by extracellular deposition of misfolded transthyretin amyloid fibrils, leading to progressive organ dysfunction. Cardiac involvement is common and may result in restrictive cardiomyopathy, arrhythmias, and conduction disturbances, including left bundle branch block (LBBB). Although pharmacological therapy with transthyretin stabilizers, such as tafamidis, has been shown to reduce mortality in patients with ATTRwt cardiac amyloidosis (ATTRwt-CA), the role of device-based therapies, such as cardiac resynchronization therapy (CRT), remains controversial, particularly in patients with coexisting conduction abnormalities.

Refractive error and axial length prediction using fundus parameters of normal eyes in the Kumejima population study.

Purpose: To evaluate the accuracy of predictive refractive error (RE) and axial length (AL) using regression analysis of fundus parameters in the Kumejima study and to identify RE- or AL-related fundus changes.

Study Design: Prospective cross-sectional observational population study.

Methods: Non-mydriatic color fundus photographs (CFPs) from 1,646 right eyes of healthy Kumejima participants were analyzed.

Erratum: Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4.

[This corrects the article DOI: 10.1016/j.isci.

Clinical characteristics and interdepartmental collaboration for patients with Anderson-Fabry disease in Shiga Prefecture, Japan.

Purpose: Anderson-Fabry disease (AFD) is an X-linked lysosomal-storage disease caused by pathogenic variants in the gene encoding alpha-galactosidase A (). The purpose of this study was to investigate the clinical characteristics of patients with AFD and the types of medical specialists necessary to manage them in a prefecture with a population of 1.48 million.

Five-year effect of sequential argon-Nd:YAG prophylactic laser peripheral iridotomy on corneal endothelial cell density in Japanese eyes with narrow angles.

Purpose: To evaluate the effects of prophylactic sequential argon- Nd:YAG laser peripheral iridotomy (pLPI) on the corneal endothelial cell density (CECD) over 5 years in Japanese eyes with narrow angles (NA-eyes).

Study Design: Prospective observational study METHODS: The CECD of NA-eyes before and after pLPI and of untreated NA-eyes were assessed annually over 5 years with non-contact specular microscopy. Routine ophthalmic examinations and measurements using anterior-segment imaging devices were performed at baseline.

Usefulness of preoperative peripheral blood GPC3-positive circulating tumor cells in subclassification of Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma: a retrospective cohort study.

Aim: The treatment strategy for hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) stage B, representing the intermediate stage, remains unclear. This study aimed to evaluate the utility of glypican-3 (GPC3)-positive circulating tumor cells (CTCs) in subclassifying BCLC stage B.

Methods: The present retrospective cohort study included patients with hepatocellular carcinoma who underwent primary liver resection at our hospital between April 2015 and March 2022.

Wound, Pressure Ulcer and Burn Guidelines (2023)-5: Guidelines for the Management of Lower Leg Ulcers/Varicose Veins, Third Edition Wound/Pressure Ulcer/Burn Guidelines Drafting Committee (Lower Leg Ulcers/Varicose Veins Group).

Guidelines for the management of lower leg ulcers/varicose veins, third edition is a fully revised guideline drafted by the Japanese Dermatological Association Wound/Pressure Ulcer/Burn Guidelines Drafting Committee. They were developed in a systematic and transparent manner with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. In the four clinical questions with meta-analyses, ultrasonography, compression therapy, surgical therapy, and sclerotherapy were weakly recommended in the treatment of lower leg ulcers/varicose veins.

The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis.

Apoptotic chromatin condensation inducer 1 (Acin1) is an RNA-binding protein involved in the regulation of alternative splicing, but its physiological function remains unclear. Global deletion of Acin1 causes embryonic lethality around E11.5, with mutants exhibiting developmental delays and increased apoptosis.

Recurrent Liver Abscess Caused by Mucoid-Type Klebsiella pneumoniae Successfully Treated With Hepatic Artery Antibiotic Infusion Therapy: A Case Report.

Liver abscesses typically respond well to a combination of antibiotics and drainage. However, some cases can be resistant to treatment and pose a clinical challenge. Infections caused by mucoid-type are rare, but highly invasive, and can lead to conditions such as liver abscesses and hematogenous dissemination, resulting in systemic complications.

Tire-based microplastics: Composition, detection, and impacts of advanced oxidation processes in drinking water treatment.

Microplastic pollution, particularly that from tire, presents critical environmental and public health concerns. They contribute 60 % of the total microplastic pollution. Tire-based microplastics, which contain synthetic polymers and toxic chemical additives, are significant contributors to microplastic pollution in aquatic systems.

Abating a micropollutant epinastine by UV-based advanced oxidation processes: Comparison for UV/hydrogen peroxide, UV/persulfate, and UV/chlorine, impacts of bromide contents, and formation of DBPs during post-chlorination.

Anthropogenic organic compounds, such as pharmaceuticals and personal care products, contaminate water, posing toxicological risks caused by either their parent compounds or transformation products. This study compares ultraviolet (UV)-based advanced oxidation processes (UV/hydrogen peroxide, UV/persulfate, and UV/chlorine) for the abatement of an antihistamine drug epinastine. UV light at 254 nm was irradiated upon solutions containing 10 μM epinastine and 100 μM oxidant.

A phase I/II study of adoptive immunotherapy using donor liver graft-derived NK cell-enriched immune cells to prevent severe infection after liver transplantation.

Bloodstream infections (BSIs) are significant postoperative complications associated with high mortality rates after liver transplantation (LT). Natural killer (NK) cells, which are key components of the innate immune system, have demonstrated potential to combat both infections and cancer. The use of activated NK cells to mitigate post-LT infections, particularly BSIs, has attracted considerable interest.

The steatosis-associated fibrosis estimator score is a useful indicator of recurrence and survival after initial curative hepatectomy for hepatocellular carcinoma.

Aims: Liver fibrosis predisposes patients to liver failure and hepatocellular carcinoma. Various markers, which can be calculated easily from serum parameters, have been reported to predict liver fibrosis accurately. This study investigated the prognostic factors, including blood-based markers for liver fibrosis of patients with hepatocellular carcinoma following initial curative hepatectomy.

Comparison of reference libraries for the detection of tire-derived microplastics (TMPs).

Introducing microplastics (MPs) into the marine environment is a global problem. Tire-derived microplastics (TMPs) are estimated to account for 60% of all secondary MPs dispersed in aquatic environments. To effectively detect TMPs in environmental samples using micro-Fourier transform infrared (μFTIR) spectroscopy, a high-quality reference library is essential.

Association of PIRCHE-II score with anti-donor T-cell response and risk of de novo donor-specific antibody production in kidney transplant recipients.

Background: De novo donor-specific antibodies (dnDSAs) affect long-term outcomes of kidney transplantation (KT). A higher Predicted Indirectly ReCognizable Human Leukocyte Antigen (HLA) Epitopes (PIRCHE-II) score correlates with various clinical outcomes, including dnDSA formation. However, a detailed analysis of the relationship between the PIRCHE-II score and anti-donor T-cell response is lacking.

Polymorphisms in genes involved in regulating follicular helper T cell differentiation predict de novo donor-specific antibody formation after liver transplantation.

Background: De novo donor-specific antibodies (dnDSAs) significantly affect the long-term outcomes of liver transplantation (LT), highlighting the importance of risk prediction. Follicular helper T (Tfh) cells have been implicated in dnDSA formation after transplantation. Considering the influence of immune response gene polymorphisms on transplantation outcomes, we investigated the association between polymorphisms in Tfh cell-related genes and dnDSA formation after LT.

Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals.

Purpose: To explore the frequency and positions of genetic mutations in CYP1B1 and FOXC1 in a Japanese population.

Study Design: Molecular genetic analysis.

Methods: Genomic DNA was extracted from 31 Japanese patients with childhood glaucoma (CG) from 29 families.