Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In acute myeloid leukemia, the burden of CD34+CD38- leukemia stem cells (LSC) has prognostic value at diagnosis and after induction chemotherapy. Since different methods of LSC quantification have been proposed, we determined the prognostic value on overall survival and incidence of relapse of these methods across ELN2017 risk groups, using data from the HOVON-SAKK132 trial. In addition, we have evaluated the optimal number of acquired white blood cells for accurate LSC detection and the prognostic value of individual LSC markers. Results show that acquiring 1 million white blood cells is essential for accurate LSC-negativity assessment. Among different LSC markers, CD44 overexpression on CD34+CD38- cells was the only insignificant marker in our panel. Testing the impact of several published variations on the analysis for LSC assessments on prognostic value for overall survival and cumulative incidence of relapse, showed marginal differences, demonstrating the robust prognostic value of LSC burden. For further clinical implementation, the optimal LSC assessment may differ among ELN risk groups. In conclusion, LSC burden is a robust prognostic factor and insight in the different methods of LSC definition can facilitate the clinical implementation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3324/haematol.2024.287090 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transition behavior of the waiting time distribution in a stochastic model with the internal state.
J Math Biol
September 2025
School of Mathematical Sciences and Institute of Natural Sciences, MOE-LSC, CMA-Shanghai, Shanghai Jiao Tong University, Shanghai, China.
It has been noticed that when the waiting time distribution exhibits a transition from an intermediate time power-law decay to a long-time exponential decay in the continuous time random walk model, a transition from anomalous diffusion to normal diffusion can be observed at the population level. However, the mechanism behind the transition of waiting time distribution is rarely studied. In this paper, we provide one possible mechanism to explain the origin of such a transition.
View Article and Find Full Text PDFInterVelo: A Mutually Enhancing Model for Estimating Pseudotime and RNA Velocity in Multi-Omic Single-Cell Data.
Bioinformatics
September 2025
Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Motivation: RNA velocity has become a powerful tool for uncovering transcriptional dynamics in snapshot single-cell data. However, current RNA velocity approaches often assume constant transcriptional rates and treat genes independently with gene-specific times, which may introduce biases and deviate from biological realities. Here, we present InterVelo, a novel deep learning framework that simultaneously learns cellular pseudotime and RNA velocity.
View Article and Find Full Text PDFPhylogenomic insights from the complete chloroplast genome of (poaceae: bambusoideae: arundinarieae) in Taiwan.
Mitochondrial DNA B Resour
September 2025
Department of Forestry and Nature Resources, National Chiayi University, Chiayi, Taiwan.
Hayata 1916 is a unique bamboo species endemic to Taiwan, typically found at elevations ranging from 500 to 1,500 meters. This study provides a detailed analysis of the complete chloroplast genome of for the first time. The genome spans 139,664 base pairs (bp) and consists of a large single-copy (LSC) region of 83,192 bp, a small single-copy (SSC) region of 12,869 bp, and two inverted repeat (IR) regions, each 21,798 bp in length.
View Article and Find Full Text PDFComparison of surgical outcomes between robotic and laparoscopic sacrocolpopexy with concomitant total hysterectomy for pelvic organ prolapse: A retrospective cohort study.
J Obstet Gynaecol Res
September 2025
Department of Obstetrics and Gynecology, Kawasaki Medical School, Okayama, Japan.
Aim: This study aimed to compare short- and long-term surgical outcomes between robotic sacrocolpopexy (RSC) and laparoscopic sacrocolpopexy (LSC), performed with concomitant total hysterectomy, in patients with symptomatic pelvic organ prolapse (POP).
Methods: This retrospective cohort study included 167 women who underwent RSC (n = 113) or LSC (n = 54) with hysterectomy for uterine prolapse at Kawasaki Medical University between March 2020 and December 2024. Perioperative parameters, complications (Clavien-Dindo classification), and POP recurrence were assessed.
Effect of comorbidities and multimorbidity on bone mineral density in patients with osteoporosis.
Arch Osteoporos
September 2025
Internal Medicine Service, Río Hortega University Hospital, Valladolid, Spain.
Unlabelled: This retrospective cohort study analysed a total of 344 patients from the OSTEOMED registry with matched baseline and follow-up DXA data, finding that comorbidities such as nephrolithiasis, hypertension or coronary heart disease may influence the response to prescribed anti-osteoporotic treatment.
Purpose: To determine: 1) comorbidities associated with reduced bone mineral density (BMD), T-score and Z-score at the lumbar spine (L1 to L4 vertebrae), femoral neck and total hip; and 2) the role of multimorbidity (≥ 2 comorbidities) in reduced BMD, T-score and Z-score at the lumbar spine, femoral neck and total hip.
Methods: Retrospective cohort study analyzing patients [319 females (92.