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Primary gastric melanoma has an extremely low incidence. In this case, we describe the 18F-FDG and 68Ga-FAPI PET/MRI findings in a 43-year-old patient with primary gastric melanoma. The imaging revealed heterogeneous patterns between 18F-FDG and 68Ga-FAPI PET/MRI, emphasizing the complementary roles of dual-tracer imaging in characterizing tumor characteristics of primary gastric melanoma.
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http://dx.doi.org/10.1097/RLU.0000000000005858 | DOI Listing |
Clin J Gastroenterol
September 2025
Department of Gastroenterology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita City, Akita, Japan.
Primary gastric squamous cell carcinoma (GSCC) or gastric adenosquamous carcinoma (GASC) is an uncommon histologic type for which no standard treatment has been established. The prognosis is poor, and there are few reports of effective treatment. Here, we experienced a case of GASC that was diagnosed preoperatively as GSCC and could be operated on after successful preoperative chemotherapy with pembrolizumab, 5-fluorouracil, and cisplatin.
View Article and Find Full Text PDFESMO Open
September 2025
Saint Antoine Hospital, Assistance Publique Hôpitaux de Paris (APHP), Sorbonne Université, Paris, France; Unité Mixte de Recherche Scientifique 938, SIRIC CURAMUS, Paris, France.
Background: Immune checkpoint inhibitors (ICIs) represent a paradigm shift and a therapeutic revolution in the management of mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC), and therefore for patients with Lynch syndrome (LS). The risk of developing metachronous cancers and colorectal polyps in a population of LS patients treated with ICI(s) is not well understood.
Materials And Methods: In a single-center cohort study, we retrospectively reviewed 93 LS patients from the prospective 'ImmunoMSI' cohort, who were diagnosed with dMMR/MSI-H gastrointestinal cancer and were treated with ICIs for index metastatic gastrointestinal cancer between February 2015 and April 2024.
Eur J Gastroenterol Hepatol
August 2025
Department of Medical and Surgical Sciences, University of Bologna.
Background: Gastric cancer epidemiology evolved rapidly in the last century, shifting from being one of the main causes of cancer-related death to the sixth in high-income countries.
Methods: We conducted a narrative review on gastric cancer epidemiology. Our review focused on trends of gastric cancer and its relationship with Helicobacter pylori infection; cardia and noncardia gastric cancer risk factors; early onset gastric cancer; second primary cancers in patients with gastric cancer; and implementation of gastric cancer prevention strategies.
Surg Case Rep
September 2025
Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Toyama, Japan.
Introduction: There are no reports of patients undergoing McKeown esophagectomy for esophageal cancer after undergoing pancreaticoduodenectomy for pancreatic cancer. We report the case of a patient who underwent subtotal esophagectomy and colon reconstruction after pancreaticoduodenectomy using the mesenteric approach.
Case Presentation: A 71-year-old male was diagnosed with advanced esophageal cancer.
Obes Surg
September 2025
Department of General and Visceral Surgery, University Hospital Brandenburg an der Havel, Brandenburg an der Havel, Germany.
Background: Perioperative antibiotic prophylaxis (PAP) prior to laparoscopic gastric bypass surgery is still under debate due to a lack of high evidence. Thus, the study at hand aimed to find out whether this medication lowers the rate of postoperative complications or not.
Methods: In 2020, a retrospective analysis took place at Helios Hospital Berlin Buch, Germany.