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Cholera is a life-threatening form of diarrhoea resulting from a bacterial infection of the gastrointestinal system caused by Vibrio cholerae. The aim of this article is to explore the dynamic characteristics of cholera disease transmission and the equilibrium level of recovery in a stochastic cholera framework by adopting piecewise fractional differential operator approaches. Firstly, we provide a detailed fractional-order form of the cholera model, showing the system's positivity and boundedness. Meanwhile, equilibrium analysis is performed to comprehend the model's behaviour and stability for disease-free as well as endemic-free equilibrium. Bacterial development rates have been reported to correlate with the Allee phenomenon. The resulting system exhibits multi-stability for forward and saddle-node bifurcations based on various settings. Global sensitivity is calculated employing the partial rank correlation coefficient approach. Furthermore, the model analyzes a stochastic fractional cholera system. Through a rigorous analysis, we demonstrate that the stochastic model offers a unique global positive solution. Lyapunov function theory is used to create criteria that ensure the model's unique erogodic stationary distribution at [Formula: see text]. Afterwards, the phenomenon that excessive noises can result in the elimination of cholera is discovered. Moreover, this model enables us to study a range of behaviors, from bridging to unpredictability, helping us to understand and predict the process from the beginning to the end of the virus. Moreover, the piecewise differential operators have chosen to extend novel pathways for researchers across several fields, enabling them to convey unique features in various time periods. These operators can be gathered with classical, Caputo, Atangana-Baleanu-Caputo fractional derivative, and random perturbation. As a result, the analytical insights are validated using computational modeling, providing a novel viewpoint on spreading diseases in a societal environment.
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http://dx.doi.org/10.1038/s41598-025-89286-5 | DOI Listing |
Open Med (Wars)
September 2025
University Museum System of Siena (SIMUS), History of Medicine, University of Siena, Siena, Italy.
Background And Objective: The World Health Organization (WHO) appeal of January 15, 2024, stated "The current number, size and concurrence of multiple outbreaks, the spread to areas free of cholera for decades and alarmingly high mortality rates present a major threat to global health security." The current state is extremely worrying, considering the difficulties of countries in dealing with cholera epidemics due to the lack of funding and the difficulty in oral cholera vaccine production and administration. This study aims to analyse the past and current influence of anthropization on cholera onset.
View Article and Find Full Text PDFJ Comp Neurol
September 2025
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Hummingbirds (family Trochilidae) are easily recognized due to their unique ability to hover. Critical to hovering flight is head and body stabilization. In birds, stabilization during flight is mediated, among other things, by the detection of optic flow, the motion that occurs across the entire retina during self-motion.
View Article and Find Full Text PDFIn this letter, the pull-off forces of adsorbed films of four Bap1-inspired peptides in various solvents were investigated on negatively charged mica substrates using the surface forces apparatus (SFA), complemented with dynamic light scattering (DLS) for characterizing the aggregation behavior of peptides in solution. Bap1-inspired peptides consisted of the 57 amino acid wild-type sequence (WT); a scrambled version of the WT used to investigate the impact of the primary amino acid sequence in pull-off forces (Scr); a ten amino acid sequence rich in hydrophobic content (CP) of the WT sequence, and an eight amino acid sequence (Sh1) that corresponds to the pseudo-repeating sequence in the 57 AA. SFA results showed remarkable pull-off forces for CP, particularly in the presence of salts: measured pull-off forces were 26.
View Article and Find Full Text PDFAm J Trop Med Hyg
September 2025
Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Access to safely managed drinking water is critical for preventing the spread of cholera. In October 2017, a cholera outbreak was declared in Lusaka, Zambia. As a part of response efforts, emergency water tanks were installed across Lusaka to supply treated water to community members.
View Article and Find Full Text PDFPLoS Pathog
September 2025
Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, New Jersey, United States of America.
Ethanolamine signaling through the transmembrane quorum-sensing receptor CqsR influences Vibrio cholerae niche recognition and host colonization. In this study, we present a comprehensive structure-function analysis of CqsR. Specifically, we have determined X-ray crystal structures of the CqsR periplasmic domain bound to the signaling agonist ethanolamine and its analogs, serinol and L-alaninol, as well as the ligand-free (apo) form of CqsR.
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