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Article Abstract
The dysregulated production of reactive oxygen species (ROS) during viral infections may lead to immune cell death and ineffective host responses. ROS dynamics have been under-investigated in severe Ebola virus disease (EVD), a condition in which hyperinflammation and excessive immune cell death are well described but poorly understood. Through ex vivo immunohistochemistry and in vivo ROS-sensitive magnetic resonance imaging (MRI) we demonstrate significant ROS-related oxidative changes in the spleens of domestic ferrets exposed to Ebola virus (EBOV). By immunohistochemistry or MRI, detection of splenic ROS was inversely correlated with the number of CD4/CD8 T lymphocytes and apoptotic CD8 lymphocytes, but detection was positively correlated with the frequency of apoptotic CD4 cells and the number and frequency of apoptotic B lymphocytes. These results suggest that ROS-induced apoptosis may contribute to the loss of splenic CD4 T lymphocytes in EBOV-exposed ferrets and warrant further investigation of the role of ROS in severe EVD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021656 | PMC |
| http://dx.doi.org/10.1038/s44303-025-00079-x | DOI Listing |
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