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Background: Multiple sclerosis is a chronic, complex neurological disease, often presenting with both visible and non-visible symptoms that significantly affect daily functioning. A holistic approach to multiple sclerosis care is essential for patient well-being, particularly in the unique sociocultural context of the United Arab Emirates, where factors such as insurance coverage and specialist availability can present additional challenges.
Methodology: A retrospective, service-improvement study of 81 individuals with multiple sclerosis was conducted at a specialized center in the United Arab Emirates to evaluate demographics, disease management practices, and support services. Data were extracted from electronic medical records covering the period from January 1, 2022, to January 1, 2024, and assessed against established quality measures, including crucial screening procedures recommended by the American Academy of Neurology's Quality Measurement Set.
Results: Significant gaps were identified in essential multiple sclerosis care, particularly in consultations about employment challenges, sexual dysfunction screening, and cognitive function assessment. Of the 81 participants, 43 (53.09%) were women, and 38 (46.91%) were men, with a mean age of 40.09 years. Analysis of the Expanded Disability Status Scale scores showed no significant association with blood pressure (P=0.1067) or glycemic status (P=0.3891), but a positive correlation with age (P=0.0099).
Conclusion: An integrated, multidisciplinary model of multiple sclerosis care is crucial, emphasizing regular assessments of cognitive function, fatigue, sexual health, and work-related issues to optimize patient outcomes and enhance overall brain health in the United Arab Emirates. Additionally, systematic policy interventions that mandate comprehensive screening protocols could further strengthen care delivery. Such measures may foster earlier detection of hidden disabilities and better coordination among diverse healthcare professionals, ultimately improving the quality of life for individuals with multiple sclerosis.
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http://dx.doi.org/10.7759/cureus.81201 | DOI Listing |
Chem Biodivers
September 2025
Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, Laboratory of Anti-Allergy Functional Compounds, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Autoimmune diseases (AIDs), defined by irregularities in immune system function, pose a substantial health challenge worldwide, impacting millions with persistent and frequently debilitating conditions. Conventional treatments, such as glucocorticoid-based immunosuppressive therapies, are associated with notable drawbacks and limitations. In response to these difficulties, recent scientific efforts have increasingly focused on natural compounds as potential therapeutic agents.
View Article and Find Full Text PDFNeurol Neuroimmunol Neuroinflamm
November 2025
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Background And Objectives: Myelitis is a relatively common clinical entity for neurologists, with diverse underlying causes. The aim of this study was to describe the incidence of myelitis, its causes, clinical presentation, and factors predicting functional outcomes and relapses.
Methods: Using the Swedish National Patient Registry, we identified all adult patients in Stockholm County between 2008 and 2018 using International Classification of Diseases, 10th Edition (ICD-10) codes likely to include myelitis.
Neurol Neuroimmunol Neuroinflamm
November 2025
Departments of Neurology and Ophthalmology, NYU Grossman School of Medicine, NY; and.
Background And Objectives: While reductions in optical coherence tomography (OCT) pRNFL and ganglion cell-inner plexiform layer thicknesses have been shown to be associated with brain atrophy in adult-onset MS (AOMS) cohorts, the relationship between OCT and brain MRI measures is less established in pediatric-onset MS (POMS). Our aim was to examine the associations of OCT measures with volumetric MRI in a cohort of patients with POMS to determine whether OCT measures reflect CNS neurodegeneration in this patient population, as is seen in AOMS cohorts.
Methods: This was a cross-sectional study with retrospective ascertainment of patients with POMS evaluated at a single center with expertise in POMS and neuro-ophthalmology.
Clin Transplant
September 2025
Centro De Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico.
ACS Chem Neurosci
September 2025
Department of Medical Biology, Faculty of Medicine, Bahçeşehir University, Istanbul 34353, Turkey.
IL-17A is a pro-inflammatory cytokine that significantly contributes to the pathogenesis of autoimmune diseases, including multiple sclerosis (MS). Previous studies have suggested that PARP-1 inhibitors can modulate IL-17A-mediated inflammation, prompting the investigation of Niraparib, an FDA-approved PARP-1 inhibitor, as a potential therapeutic agent for MS. In this study, we hypothesized that Niraparib could disrupt the interaction between IL-17A and its receptor, IL-17RA.
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