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Solid fluidization is a green mining developed method for seabed nondiagenetic gas hydrate reservoirs, which can safely and controllably transport hydrate to land through seabed mining, closed fluidization, and gas-liquid-solid multiphase lift. However, there are many technical problems, such as hydrate and sediment fluidization and improvement of pipeline transportation capacity in the process of multiphase lift. Based on forced spiral flow in a vertical pipe, the numerical simulation of hydrate and sediment slurry in a vertical pipe with a twisted tape is carried out to explore the solid-carrying capacity of spiral flow and expand the safe boundary of multiphase flow. The effects of hydrate volume fraction, Reynolds number, hydrate particle size, and sediment particle size on turbulent kinetic energy, turbulent dissipation, solid volume fraction, and pressure of hydrate-sediment slurry have been studied. The results show that turbulent kinetic energy and turbulent dissipation decrease with the increase of hydrate volume fraction. The turbulent kinetic energy and turbulent dissipation increase with the increase of the Reynolds number. The concentration gradient of hydrate and sediment at the outlet section is larger than that of the horizontal spiral pipe. The hydrate particle volume fraction at the hydrate axis increases with the increase of hydrate volume fraction, Reynolds number, and hydrate particle size. Sediment particles are mainly distributed near the pipe wall, and hydrate particles are mainly distributed on the inner side of the sediment and form a high-concentration ring. The pressure change in the vertical pipe is similar to that in the horizontal pipe. When = 30,000, the critical volume fraction of hydrate blockage in the vertical pipe is 47%, while the critical volume fraction is 22% in the vertical smooth pipe. The transport capacity of hydrate particles is increased by 1.14 times. Under the same conditions, the pressure drop of the whole pipe exceeds that of the ordinary smooth pipe by about 15%.
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http://dx.doi.org/10.1021/acsomega.5c00150 | DOI Listing |
JACC Case Rep
September 2025
Cardiovascular Division, Department of Medicine, Froedtert and Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:
Baroreflex activation therapy (BAT) improves functional status, quality of life, and exercise capacity in patients with heart failure with reduced ejection fraction; however, its direct effects on reversing adverse cardiac remodeling as assessed by improvements in cardiac structure, function, and coupling with the arterial system remain unclear. We present 2 cases of patients who initially presented with decompensated heart failure, and despite initial medical therapy and continued outpatient follow-up, were unable to tolerate full escalation of guideline-directed medical therapy. The patients remained symptomatic, with high biomarker levels, poor functional capacity, severe heart failure symptoms, and objectively had decreased stroke volume, low left ventricular ejection fraction, and high left ventricular mass.
View Article and Find Full Text PDFKardiologiia
September 2025
Second Affiliated Hospital of Chongqing Medical University, Department of Ultrasound Medicine.
Objective This research investigated the application of real-time, three-dimensional speckle tracking imaging (RT-3D-STI) to evaluate left atrial (LA) function in individuals suffering from hypertensive heart disease (HHD) and heart failure with preserved ejection fraction (HFpEF).Material and methods This retrospective study included 100 patients with HHD and HFpEF hospitalized from August 2023to June 2024 (HFpEF group). 100 healthy individuals undergoing physical examinations comprised the control group.
View Article and Find Full Text PDFAim To determine the prevalence and predictors for the development of newly diagnosed chronic heart failure (CHF) in patients with shortness of breath in long-term post-COVID syndrome.Material and methods This screening cross-sectional clinical study was performed from April 2020 through April 2024, in two stages in an outpatient setting. At the first stage, 878 patients with shortness of breath were screened three or more months after COVID-19, and the presence of at least three diagnostic criteria for CHF, that were not in their history, was verified.
View Article and Find Full Text PDFAim Search for subclinical manifestations of cardiotoxicity in cancer patients at high and very high risk of cardiotoxicity and evaluation of the effectiveness of drug primary prevention during the antitumor treatment. Material and methods The study included 150 cancer patients with a high and very high Mayo Clinic (USA) Cardiotoxicity Risk Score. The main group consisted of 84 patients at high and very high risk of cardiotoxicity who were prescribed cardioprotective therapy, including a fixed combination of the angiotensin-converting enzyme inhibitor (ACEI) perindopril and the beta-blocker bisoprolol with trimetazidine.
View Article and Find Full Text PDFMult Scler
September 2025
Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, USA.
Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).
Objectives: To evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.
Methods: A total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.