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Objective: Smartphone applications (apps) show promise as an effective and scalable intervention modality for disordered eating, yet responsiveness varies considerably. The ability to predict user responses to app-based interventions is currently limited. Machine learning (ML) techniques have shown potential to improve prediction of complex clinical outcomes. We applied ML techniques to predict responsiveness to a dialectical behaviour therapy-based smartphone app for recurrent binge eating.
Method: Data were collected as part of a randomised controlled trial (RCT). The present sample was based on data from 576 participants with recurrent binge eating. 10 common classification and regression approaches were used to predict outcomes that represent key stages of the user experience, including initial intervention uptake, app adherence, study drop-out, and symptom change. Models were developed using 69 self-reported baseline variables (i.e., demographic, clinical, psychological) and several app usage variables (i.e., number of modules completed) as predictors.
Results: All models, using only baseline predictors, performed sub-optimally at predicting engagement (AUCs = 0.48-0.61; R = 0.00-0.04) and symptom level change (R = 0.00-0.07). Incorporating usage data improved prediction of study dropout (AUC = 0.69-0.76).
Conclusion: ML models were unable to accurately predict responsiveness using self-reported baseline predictors alone. Predicting outcomes with greater precision may require consideration of how predictors change over time and interact with a user's context. Modelling usage pattern data appears to improve prediction of dropout, highlighting the potential value of tracking intervention usage to identify individuals at risk of disengagement.
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http://dx.doi.org/10.1016/j.brat.2025.104755 | DOI Listing |
Background: Telephone-based Cognitive Behavioral Therapy (Tele-CBT) has shown to reduce disordered eating and psychological distress after metabolic and bariatric surgery (MBS). However, it is currently unknown how Tele-CBT impacts outcomes long term, and if differences in weight loss trajectories following Tele-CBT emerge with a long-term follow-up. This study aimed to identify whether Tele-CBT remains effective at 18 months post-intervention for improving psychological distress and maladaptive eating, and mitigating recurrent weight gain.
View Article and Find Full Text PDFJ Mol Biol
August 2025
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. Electronic address:
Protein kinase A (PKA) is essential in converting extracellular signals into tightly regulated cellular responses controlling vital processes such as growth, development, and gene expression. Activation of PKA is controlled by the binding of cAMP to the regulatory subunit of PKA (R). Several mutations in the ubiquitous RIα isoform of R cause Acrodysostosis 1 (ACRO), a disease characterized by resistance to thyroid-stimulating and parathyroid hormones leading to severe congenital malformations.
View Article and Find Full Text PDFObes Surg
August 2025
Department of Psychiatry, University of São Paulo Medical School, University of São Paulo, Brazil.
Objective: To investigate the applicability of group cognitive-behavioral therapy (CBT) delivered through an online intervention on mental health symptoms and weight change in patients who experienced recurrent weight gain four years after metabolic and bariatric surgery.
Methods: Participants were recruited from a university bariatric center. Of the 142 postoperative patients assessed, 33 had regained 15% of the total weight lost from their lowest postoperative weight.
Clin Psychol Rev
August 2025
Center for Biobehavioral Research, Sanford Research, 120 8th Street S., Fargo, ND 58122, United States of America; Department of Psychiatry, University of North Dakota School of Medicine and Health Sciences, 1301 N. Columbia Road, Grand Forks, ND 58202, United States of America.
Binge eating disorder (BED) is characterized by recurrent binge eating episodes. Many factors have been analyzed in the maintenance of binge eating disorder, but current treatments still fall short of optimal success rates, with approximately half of individuals with BED relapsing following intervention. Perhaps partially due to the many shared vulnerabilities and high rates of comorbidity, interventions of BED have increasingly incorporated strategies utilized in substance use disorder treatment and indeed, there are many overlapping components in prevailing theories of BED and addiction.
View Article and Find Full Text PDFFront Med (Lausanne)
July 2025
Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
Introduction: Acute gastric dilatation (AGD) is a rare but clinically significant condition characterized by abnormal enlargement of the stomach. It can lead to serious complications such as gastric necrosis, perforation, and respiratory failure if not promptly managed. AGD has been associated with mechanical obstructions, binge eating, and systemic conditions like diabetes mellitus.
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