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: Recent advancements have significantly enhanced our understanding of the interplay between inflammatory bowel disease (IBD) and reproductive health. While international organizations provide guidelines for best practices, translating them into actionable strategies is crucial. This study aimed to develop a comprehensive care pathway to enhance preconception counselling and support for patients with IBD in the perinatal period, ensuring they receive optimal expert care. : We used the 7-phase model for the development of the care pathway. : The resulting care pathway, structured as a time-task matrix, outlines the required actions at preconception, during pregnancy, and in the postpartum period for women with IBD. The pathway provides a structured and multidisciplinary approach that addresses the unique needs of patients with IBD of childbearing age. It emphasizes holistic and personalized support throughout the preconception, pregnancy, and postpartum period. : The development of this care pathway represents a significant advancement in the perinatal management of IBD. By offering multidisciplinary and individualized care, optimal maternal and infant outcomes are pursued, while establishing a new global standard for reproductive health and perinatal management.
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http://dx.doi.org/10.3390/jcm14082644 | DOI Listing |
Inflamm Bowel Dis
September 2025
Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Background: Intestinal cells receive incoming signals from neighboring cells and microbial communities. Upstream signaling pathways transduce these signals to reach transcription factors (TFs) that regulate gene expression. In inflammatory bowel disease (IBD), most single nucleotide polymorphisms (SNPs) are in non-coding genomic regions containing TF binding sites.
View Article and Find Full Text PDFHealth Soc Care Deliv Res
September 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: Remote services (in which the patient and staff member are not physically colocated) and digital services (in which a patient encounter is digitally mediated in some way) were introduced extensively when the COVID-19 pandemic began in 2020. We undertook a longitudinal qualitative study of the introduction, embedding, evolution and abandonment of remote and digital innovations in United Kingdom general practice. This synoptic paper summarises study design, methods, key findings, outputs and impacts to date.
View Article and Find Full Text PDFDrug Deliv Transl Res
September 2025
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 300044, Taiwan.
The three-dimensional (3D) culture system has emerged as an indispensable platform for modulating stem cell function in biomedicine, drug screening, and cell therapy. Despite a few studies confirming the functionality of 3D culture, the molecular factors underlying this process remain obscure. Here, we have utilized a hanging drop method to generate 3D spheroid-derived mesenchymal stem cells (3D MSCs) and compared them to conventionally 2D-cultured MSCs.
View Article and Find Full Text PDFRev Infirm
September 2025
CHRU de Nancy, Service de neurologie, Unité de prise en charge des interactions neuropsychiatriques ACT N'PSY, 29 avenue du Maréchal-de-Lattre-de-Tassigny, CO 60034, 54035 Nancy, France. Electronic address:
At the crossroads of neurology and psychiatry, functional neurological disorders (FND) require detailed, coordinated management. Through the experience of the ACT N'PSY unit, this article shows how nurses, and in particular advanced practice nurses (APNs), are becoming key players: from psycho-education to clinical follow-up, coordination and networking, they are boosting the efficiency of care paths.
View Article and Find Full Text PDFFish Shellfish Immunol
September 2025
Laboratory of Applied Immunology in Aquaculture, Department of Cell Biology, Embryology and Genetics, Federal University of Santa Catarina, 88035-972 Florianópolis, SC, Brazil. Electronic address:
Environmental and nutritional factors are critical in modulating the immune system of Penaeus vannamei, particularly under viral threats such as white spot syndrome virus (WSSV). This study evaluated the effects of two Amazonian plant-based feed additives, buriti (Mauritia flexuosa) and pracaxi (Pentaclethra macroloba) brans, on shrimp immunocompetence, oxidative balance, and resistance to WSSV. Shrimp were fed diets supplemented with 4% or 8% of each ingredient.
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