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Article Abstract
The mutant eye color trait ( ) was first observed by Calvin Bridges over a century ago. Although mutant strains have been maintained ever since, the locus has not been identified. Using complementation tests, genetic rescue, and DNA sequencing, we show that is a missense mutation in ; this gene encodes a key component of the SNARE complex, which facilitates vesicle docking and fusion at cellular membranes. After describing how was mapped, we discuss ways that the mutation could be used in future studies of eye pigmentation, SNARE complex assembly, and vesicle trafficking.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12015646 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001563 | DOI Listing |
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