Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To evaluate the clinicopathological and prognostic significance of preoperative serum Midkine levels in patients with colorectal cancer.
Methods: Preoperative Midkine levels were analyzed using an enzyme-linked immunosorbent assay in 78 patients with colorectal cancer, at stages 0 (n = 2), I (n = 19), II (n = 25), III (n = 24), and IV (n = 8). Using a cut-off value of 421 pg/mL, the patients were divided into a Midkine(+) group and a Midkine(-) group. Clinicopathological factors and prognosis were compared between the two groups, using univariate and multivariate analyses.
Results: The overall positive rates were 46%, 32%, and 21% for CEA, Midkine, and CA19-9, respectively. The positive rate of the Midkine/CEA combination was 55%. The positive rates at stage 0/I were 19%, 19%, and 5% for CEA, Midkine, and CA19-9, respectively. The Midkine(+) group showed poor survival, but the differences were not significant. The Midkine (+)/CEA (+) group had significantly worse relapse-free survival (RFS) (p = 0.02). The Midkine (+)/CEA (+) level was an independent risk factor for RFS (p = 0.04) and overall survival (p = 0.03).
Conclusion: The Midkine (+)/CEA (+) combination may be an indicator of poor prognosis for patients with colorectal cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00595-025-03044-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Trace protein detection by graphene-integrated terahertz meta-sensor and enhanced sensitivity using gold nanoparticles-assisted.
Biosens Bioelectron
October 2025
College of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin, 300072, China.
With the rapid development of terahertz (THz) biosensing technology, the research on trace protein detection via THz metasurfaces has attracted significant attention. Here, we propose a graphene-integrated toroidal split-ring resonator (TSRR) THz meta-sensor for detecting protein at trace levels based on the Dirac property of chemical vapor deposition (CVD) graphene. The experimental results show that the designed meta-sensor can realize the detection of midkine with a 125 pg/mL limit of detection (LOD).
View Article and Find Full Text PDFAssociation between the preoperative Midkine (+)/CEA (+) level and poor prognosis in colorectal cancer patients.
Surg Today
April 2025
Department of Surgery, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan.
Purpose: To evaluate the clinicopathological and prognostic significance of preoperative serum Midkine levels in patients with colorectal cancer.
Methods: Preoperative Midkine levels were analyzed using an enzyme-linked immunosorbent assay in 78 patients with colorectal cancer, at stages 0 (n = 2), I (n = 19), II (n = 25), III (n = 24), and IV (n = 8). Using a cut-off value of 421 pg/mL, the patients were divided into a Midkine(+) group and a Midkine(-) group.
Clinical Efficacy of Bushen Yiqi Fuzheng Decoction Combined with Sunitinib in the Treatment of Postoperative Patients with Renal Cell Carcinoma and Its Influence on Their Immune Function.
Arch Esp Urol
September 2023
Lvjing Community Health Service Center, Jinan Central Hospital, Central Hospital Affiliated to Shandong First Medical University, 250013 Jinan, Shandong, China.
Background: This study aimed to investigate the effect of Bushen Yiqi Fuzheng decoction combined with sunitinib on the prognosis, clinical efficacy and immune function of patients with renal cell carcinoma (RCC) after surgery.
Methods: A total of 120 patients who experienced RCC after surgery were randomly divided into the observation and control groups in this prospective study, with 60 cases in each group. The therapeutic effect, improvement of clinical symptoms, changes of immune function-related indicators and adverse reactions during medication were recorded.
Evaluation of serum midkine and carcinoembryonic antigen as diagnostic biomarkers for rectal cancer and synchronous metastasis.
Transl Cancer Res
April 2020
Department of General Surgery, Tianjin Union Medical Center, Tianjin 300121, China.
Methods: S-MK and CEA, related to cancer status, were measured in 106 patients and 30 controls by ELISAs. Diagnostic and Prognostic values of S-MK and CEA for rectal cancer were conducted by receiver operating characteristic (ROC) curves with the analysis of sensitivity, specificity, diagnostic accuracy, positive predictive value (PPV) and negative predictive value (NPV) for differential diagnosis.
Results: Pre-surgical S-MK was elevated in cancer patients than the normal and benign subjects.
Serum Midkine is a clinical significant biomarker for colorectal cancer and associated with poor survival.
Cancer Med
March 2020
Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Colorectal carcinoma (CRC) is one of the most common carcinomas worldwide. Early detection is crucial for reducing morbidity and mortality. Several promising studies described the use of midkine (MK) as a tumor marker.
View Article and Find Full Text PDF