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Background Context: Spinopelvic alignment assessment needs to account for pelvic incidence (PI).
Purpose: This study aimed at providing normative values for commonly used parameters in whole-body alignment analysis based on PI.
Design: Multicentric prospective study.
Patient Sample: This study included healthy volunteers with full-body biplanar radiograph in free-standing position.
Outcome Measures: All radiographic data were collected from 3D reconstructions: Sagittal vertical axis (SVA), T1 pelvic angle (TPA), spino-sacral angle (SSA), sagittal odontoid-hip axis angle (ODHA), pelvic parameters, sacro-femoral angle (SFA), knee flexion angle (KFA), ankle flexion angle (AA), Pelvic shift (PSh), lumbar lordosis (LL), thoracic kyphosis (TK) and cervical lordosis (CL).
Methods: Population was divided into five groups according to PI. Normative values were described for each group. Linear regressions including age and PI provided prediction formulas for PT, TPA, SSA and SFA.
Results: 642 subjects were included. Mean age was 37.7 ± 16.3 years (range: 18-90). Mean PI in the cohort was 49.3 ± 9.5°. LL, PT, SFA, SSA and TPA correlated with PI and age. ODHA, TK, CL and the other lower limb parameters were not associated with PI. All normative values across PI groups are provided for segmental, regional and global alignment parameters. Prediction formulas were: PT=-12.7 + 0.38*PI + 0.14*Age, TPA=-16.9 + 0.34*PI + 0.15*Age, SSA = 109.8 + 0.58*PI-0.19*Age, and SFA = 173 + 0.39*PI + 0.11*Age.
Conclusions: SSA, PT, TPA and SFA must be assessed according to patient's PI. This study provides normative values for each PI group, and predictive formulas taking age and PI into account. PI cannot be used to define thoracic and cervical curvatures.
Level Of Evidence: II.
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http://dx.doi.org/10.1007/s00586-025-08872-3 | DOI Listing |
BMJ Ment Health
September 2025
Independent Researcher, Cardiff, Cardiff, UK
Background: Mental health research has long been structured around qualitative and quantitative methodologies, often marginalising experiential knowledge and reinforcing hierarchies of expertise. Although coproduction has gained traction as a participatory approach, its methodological status remains contested, leading to inconsistent practices and risks of tokenism.
Objective: This paper explores whether coproduction should be recognised not merely as a participatory ideal but as a third methodological pillar in mental health research, with distinct philosophical, ethical and practical foundations.
PLoS One
September 2025
Nationhood Lab, Pell Center for International Relations and Public Policy, Salve Regina University, Newport, Rhode Island, United States of America.
This study investigates the "First Settler Wellness Effect," exploring how cultural geography impacts traditional wellness (physical health, social relationships, and financial stability) and existential wellness (purpose, meaning, and community identity) across the United States. Using data from the Gallup-Healthways Well-Being Index, which includes responses from over 325,000 individuals across 110 Metropolitan Statistical Areas (MSAs) from 2009 to 2016, we analyze wellness outcomes through the lens of the American Nations Model. This model categorizes the United States into distinct cultural regions shaped by early settlement patterns, emphasizing the enduring influence of regional norms and ideologies.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.
JAMA Netw Open
September 2025
School of Medicine and Public Health, University of Wisconsin-Madison, Madison.
Importance: It is unclear whether the duration of amyloid-β (Aβ) pathology is associated with neurodegeneration and whether this depends on the presence of tau.
Objective: To examine the association of longitudinal atrophy with Aβ positron emission tomography (PET)-positivity (Aβ+) and the estimated duration of Aβ+ (Aβ+ duration), controlling for tau-positivity.
Design, Setting, And Participants: Data for this longitudinal cohort study were drawn from the Wisconsin Registry for Alzheimer Prevention and the Wisconsin Alzheimer Disease Research Center Clinical Core Study.
J Neurooncol
September 2025
Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA.
Purpose: Cranial irradiation is associated with health-related quality of life (HRQoL) deficits in childhood cancer survivors. We investigated the relationship between radiation dose to brain substructures and HRQoL in children with brain tumors treated with proton beam therapy (PBT).
Methods: Data were obtained from children in the Pediatric Proton/Photon Consortium Registry who received PBT for primary brain tumors between 2015 and 2021.