98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995288 | PMC |
http://dx.doi.org/10.4244/EIJ-D-24-00342 | DOI Listing |
Pol Merkur Lekarski
September 2025
BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
Objective: Aim: To find out new objective criteria for laser histological differential diagnosis of thyroid pathology based on the use of a digital method of layer-by-layer polarization-interference mapping of polarization ellipticity maps of microscopic images of native histological sections of thyroid biopsy.
Patients And Methods: Materials and Methods: Four groups of patients were studied: control group 1 - healthy donors (51 patients); study group 2 - patients with nodular goiter (51 patients); study group 3 - patients with autoimmune thyroiditis (51 patients); study group 4 - patients with papillary cancer (51 patients). Methods used: polarization-interference, statistical.
Sci Adv
September 2025
Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here, we performed single-nucleus multiomics and spatial transcriptomics in up to 32 nondiabetic (ND), autoantibody-positive (AAB), and T1D pancreas donors. Genomic profiles from 853,005 cells mapped to 12 pancreatic cell types, including multiple exocrine subtypes.
View Article and Find Full Text PDFCereb Cortex
August 2025
Section of Brain Function Information, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan.
This study aimed to identify brain activity modulations associated with different types of visual tracking using advanced functional magnetic resonance imaging techniques developed by the Human Connectome Project (HCP) consortium. Magnetic resonance imaging data were collected from 27 healthy volunteers using a 3-T scanner. During a single run, participants either fixated on a stationary visual target (fixation block) or tracked a smoothly moving or jumping target (smooth or saccadic tracking blocks), alternating across blocks.
View Article and Find Full Text PDFCereb Cortex
August 2025
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurosciences des Systèmes (INS) UMR1106, Marseille 13005, France.
Over three decades, statistical parametric mapping has transformed neuroimaging from descriptive mapping to causal inference, placing generative models at the core of causal explanations for brain function. It inspired to a large degree The Virtual Brain, which builds subject-specific digital twins from multimodal data, enabling brain simulations and exploration. Both frameworks converge at parameter estimation, where model and data meet, providing the mathematical manifestation of cause-effect in pathophysiology.
View Article and Find Full Text PDFCereb Cortex
August 2025
The Clinical Hospital of Chengdu Brain Sciences Institute, University of Electronic Sciences and Technology of China (UESTC), 2006 Xiyuan Avenue, West Hi Tech Zone, 611731, Chengdu, China.
This commentary reflects three decades of interaction between the Cuban neuroinformatics tradition and the statistical parametric mapping (SPM) framework. From the early development of neurometrics in Cuba to global initiatives like the Global Brain Consortium, our trajectory has paralleled and intersected with that of SPM. We highlight shared commitments to generative modeling, Bayesian inference, and population-level brain mapping, as shaped through collaborations, workshops, and joint theoretical work with Karl Friston and his group.
View Article and Find Full Text PDF